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Title:
METHOD FOR PREPARING PEGYLATED COLLAGEN-LIKE PROTEIN AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/035720
Kind Code:
A1
Abstract:
The present application relates to a method for preparing a pegylated collagen-like protein and the use thereof, which belong to the field of biotechnology. Provided in the present application is a method for preparing a pegylated collagen-like protein, the method comprising reacting a collagen-like protein and a polyethylene glycol derivative under the conditions of a pH of 6.0-8.0 and a temperature of 2-8°C to prepare a pegylated collagen-like protein. Comparing other existing methods for preparing the pegylated collagen-like protein, the pegylated collagen-like protein prepared by using the method of the present application has a better cross-linking performance, and after the pegylated collagen-like protein prepared by using the method of the present application is prepared into a hydrogel to form a cornea, the strength can be improved by at least 10 times compared with the pegylated collagen-like protein prepared by means of the existing methods; and in addition, the reaction time for preparing the pegylated collagen-like protein by using the method of the present application is shorter, and the pegylated collagen-like protein capable of being prepared into a hydrogel to form a cornea can be obtained merely by means of reacting for 5-8h.

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Inventors:
WANG CHONGYU (CN)
ZHANG JIAHUI (CN)
ZHANG JUN (CN)
LIU MURONG (CN)
HE CHAOXIAN (CN)
Application Number:
PCT/CN2022/099755
Publication Date:
March 16, 2023
Filing Date:
June 20, 2022
Export Citation:
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Assignee:
EOSVISION MEDTECH TECH CO LTD (CN)
International Classes:
C07K14/78; A61L27/24; A61L27/52; C07K1/107; C07K1/34
Foreign References:
CN113773379A2021-12-10
CN113735964A2021-12-03
CN113926001A2022-01-14
Other References:
SIMPSON FIONA C., MCTIERNAN CHRISTOPHER D., ISLAM MOHAMMAD MIRAZUL, BUZNYK OLEKSIY, LEWIS PHILIP N., MEEK KEITH M., HAAGDORENS MIC: "Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs", COMMUNICATIONS BIOLOGY, vol. 4, no. 1, XP093044074, DOI: 10.1038/s42003-021-02108-y
JANGAMREDDYJAGANMOHANR, SHORT PEPTIDE ANALOGS AS ALTERNATIVES TO COLLAGEN IN PRO-REGENERATIVE CORNEAL IMPLANTS
Attorney, Agent or Firm:
SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD. (CN)
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