Title:
METHOD FOR PREPARING STEROID DERIVATIVE FXR AGONIST
Document Type and Number:
WIPO Patent Application WO/2019/020067
Kind Code:
A1
Abstract:
The present invention falls within the field of pharmaceutical chemistry, and relates to a method for preparing a steroid derivative FXR agonist and the relevant intermediates. In particular, the present invention relates to a method for preparing a compound of formula I, comprising reacting a compound of formula 8 with a compound of formula 9 to obtain a compound of formula 10, obtaining a compound of formula 11 from a reaction of the compound of formula 10, and obtaining the compound of formula I from a reaction of the compound of formula 11, as well as the intermediates used, the methods for preparing the intermediates and the use of the intermediates. The reaction conditions of the preparation method are mild, and some of the steps can convert multiple groups simultaneously, thereby effectively shortening the sequence of steps. The preparation method is suitable for industrialized production. (I)
Inventors:
LI XIAOLIN (CN)
XIAO HUALING (CN)
LI PENG (CN)
HE HAIYING (CN)
HAO FEI (CN)
XIAO HUALING (CN)
LI PENG (CN)
HE HAIYING (CN)
HAO FEI (CN)
Application Number:
PCT/CN2018/097158
Publication Date:
January 31, 2019
Filing Date:
July 26, 2018
Export Citation:
Assignee:
CHIA TAI TIANQING PHARMACEUTICAL GROUP CO LTD (CN)
MEDSHINE DISCOVERY INC (CN)
MEDSHINE DISCOVERY INC (CN)
International Classes:
C07J9/00; C07J43/00
Domestic Patent References:
| WO2016161003A1 | 2016-10-06 | |||
| WO2017129125A1 | 2017-08-03 | |||
| WO2000037077A1 | 2000-06-29 |
Foreign References:
| CN106661079A | 2017-05-10 | |||
| CN105102425A | 2015-11-25 | |||
| CN106083978A | 2016-11-09 |
Other References:
DATABASE REGISTRY 23 June 2014 (2014-06-23), retrieved from STN Database accession no. RN 1612191-84-0
DJ. MANGELSDORF ET AL., CELL, vol. 83, 1995, pages 841 - 850
W. SEOL ET AL., MOL. ENDOCRINNOL, vol. 9, 1995, pages 72 - 85
"Greene's Protective Groups in Organic Synthesis", WILEY PRESS, OR PROTECTING GROUPS PUBLISHED BY CHEMICAL INDUSTRY PRESS
See also references of EP 3660030A4
DJ. MANGELSDORF ET AL., CELL, vol. 83, 1995, pages 841 - 850
W. SEOL ET AL., MOL. ENDOCRINNOL, vol. 9, 1995, pages 72 - 85
"Greene's Protective Groups in Organic Synthesis", WILEY PRESS, OR PROTECTING GROUPS PUBLISHED BY CHEMICAL INDUSTRY PRESS
See also references of EP 3660030A4
Attorney, Agent or Firm:
BEIJING SUNHOPE INTELLECTUAL PROPERTY LTD. (CN)
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