Title:
METHOD FOR PREVENTING CANCERIZATION DUE TO LOW-DOSE IRRADIATION
Document Type and Number:
WIPO Patent Application WO/2017/188516
Kind Code:
A1
Abstract:
The present invention relates to a method for preventing cancerization of normal cells due to low-dose irradiation. The method enables effective prevention of cancerization of normal cells by means of low-dose radiation which is innocuous to a subject.
Inventors:
NAM SEONYOUNG (KR)
YANG KWANG HEE (KR)
LEE SU-JAE (KR)
KIM RAE-KWON (KR)
YANG KWANG HEE (KR)
LEE SU-JAE (KR)
KIM RAE-KWON (KR)
Application Number:
PCT/KR2016/009300
Publication Date:
November 02, 2017
Filing Date:
August 23, 2016
Export Citation:
Assignee:
KOREA HYDRO & NUCLEAR POWER CO (KR)
International Classes:
C12N13/00; A61N5/10; C12N15/01
Foreign References:
| KR20130086688A | 2013-08-05 | |||
| KR20150042590A | 2015-04-21 |
Other References:
YIN, E. ET AL.: "Gene Expression Changes in Mouse Brain after Exposure to Low-dose Ionizing Radiation", INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol. 79, no. 10, October 2003 (2003-10-01), pages 759 - 775, XP055435622
CHEN, YUXIN ET AL.: "Mitochondrial Redox Signaling and Tumor Progression", CANCERS, vol. 8, no. 4, 25 March 2016 (2016-03-25), pages 1 - 15, XP055435623
SUH, YONG JOON ET AL.: "KRAS-driven ROS Promote Malignant Transformation", MOLECULAR & CELLULAR ONCOLOGY, vol. 2, no. 1, 22 January 2015 (2015-01-22), pages e968059, XP055435630
KIM, RAE-KWON ET AL.: "Beneficial Effects of Low Dose Radiation in Response to the Oncogenic KRAS induced Cellular Transformation", SCIENTIFIC REPORTS, vol. 5, 30 October 2015 (2015-10-30), pages 15809, XP055435632
KIM, RAE KWON ET AL.: "Low Dose Radiation Promotes the Reduction of Malignant Phenotypes of the Transformed Breast Epithelial Cells", IN: 2015 KOREAN SOCIETY OF RADIATION BIOSCIENCE SPRING CONFERENCE , KOREA ATOMIC ENERGY RESEARCH INSTITUTE INTERNATIONAL TRAINING CENTER, KOREAN SOCIETY OF RADIATION BIOSCIENCE, 21 May 2015 (2015-05-21), pages 43, XP055435638
CHEN, YUXIN ET AL.: "Mitochondrial Redox Signaling and Tumor Progression", CANCERS, vol. 8, no. 4, 25 March 2016 (2016-03-25), pages 1 - 15, XP055435623
SUH, YONG JOON ET AL.: "KRAS-driven ROS Promote Malignant Transformation", MOLECULAR & CELLULAR ONCOLOGY, vol. 2, no. 1, 22 January 2015 (2015-01-22), pages e968059, XP055435630
KIM, RAE-KWON ET AL.: "Beneficial Effects of Low Dose Radiation in Response to the Oncogenic KRAS induced Cellular Transformation", SCIENTIFIC REPORTS, vol. 5, 30 October 2015 (2015-10-30), pages 15809, XP055435632
KIM, RAE KWON ET AL.: "Low Dose Radiation Promotes the Reduction of Malignant Phenotypes of the Transformed Breast Epithelial Cells", IN: 2015 KOREAN SOCIETY OF RADIATION BIOSCIENCE SPRING CONFERENCE , KOREA ATOMIC ENERGY RESEARCH INSTITUTE INTERNATIONAL TRAINING CENTER, KOREAN SOCIETY OF RADIATION BIOSCIENCE, 21 May 2015 (2015-05-21), pages 43, XP055435638
Attorney, Agent or Firm:
LEE, Un Cheol (KR)
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