Title:
ONCOGENIC RAS-INDUCED MALIGNANT CANCERIZATION INHIBITION USING LOW-DOSE RADIATION
Document Type and Number:
WIPO Patent Application WO/2017/188517
Kind Code:
A1
Abstract:
The present invention relates to an apparatus, for inhibiting oncogene-induced malignant cancerization, comprising an irradiation unit which is for irradiating low-dose radiation on a subject and a method, for inhibiting oncogene-induced malignant cancerization, comprising a step for irradiating low-dose radiation on a subject. Oncogene-induced malignant cancerization can be inhibited by means of the apparatus and method of the present invention.
Inventors:
NAM SEONYOUNG (KR)
YANG KWANG HEE (KR)
LEE SU-JAE (KR)
KIM RAE-KWON (KR)
YANG KWANG HEE (KR)
LEE SU-JAE (KR)
KIM RAE-KWON (KR)
Application Number:
PCT/KR2016/009301
Publication Date:
November 02, 2017
Filing Date:
August 23, 2016
Export Citation:
Assignee:
KOREA HYDRO & NUCLEAR POWER CO (KR)
International Classes:
C12N13/00; C12N15/01
Foreign References:
| KR20130086688A | 2013-08-05 | |||
| KR20150042590A | 2015-04-21 |
Other References:
YIN, E. ET AL.: "Gene Expression Changes in Mouse Brain after Exposure to Low-dose Ionizing Radiation", INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, vol. 79, no. 10, October 2003 (2003-10-01), pages 759 - 775, XP055435622
CHEN, YUXIN ET AL.: "Mitochondrial Redox Signaling and Tumor Progression", CANCERS, vol. 8, no. 4, 25 March 2016 (2016-03-25), pages 1 - 15, XP055435623
SUH, YONG JOON ET AL.: "KRAS-driven ROS Promote Malignant Transformation", MOLECULAR & CELLULAR ONCOLOGY, (ELECTRONIC PUBLISHING, vol. 2, no. 1, 22 January 2015 (2015-01-22), pages e968059, XP055435630
KIM, RAE-KWON ET AL.: "Beneficial Effects of Low Dose Radiation in Response to the Oncogenic KRAS Induced Cellular Transformation", SCIENTIFIC REPORTS, 30 October 2015 (2015-10-30), pages 1 - 10, XP055435632
KIM, RAE KWON ET AL.: "Low Dose Radiation Promotes the Reduction of Malignant Phenotypes of the Transformed Breast Epithelial Cells", IN: 2015 KOREAN SOCIETY OF RADIATION BIOSCIENCE SPRING CONFERENCE, 21 May 2015 (2015-05-21), pages 43
CHEN, YUXIN ET AL.: "Mitochondrial Redox Signaling and Tumor Progression", CANCERS, vol. 8, no. 4, 25 March 2016 (2016-03-25), pages 1 - 15, XP055435623
SUH, YONG JOON ET AL.: "KRAS-driven ROS Promote Malignant Transformation", MOLECULAR & CELLULAR ONCOLOGY, (ELECTRONIC PUBLISHING, vol. 2, no. 1, 22 January 2015 (2015-01-22), pages e968059, XP055435630
KIM, RAE-KWON ET AL.: "Beneficial Effects of Low Dose Radiation in Response to the Oncogenic KRAS Induced Cellular Transformation", SCIENTIFIC REPORTS, 30 October 2015 (2015-10-30), pages 1 - 10, XP055435632
KIM, RAE KWON ET AL.: "Low Dose Radiation Promotes the Reduction of Malignant Phenotypes of the Transformed Breast Epithelial Cells", IN: 2015 KOREAN SOCIETY OF RADIATION BIOSCIENCE SPRING CONFERENCE, 21 May 2015 (2015-05-21), pages 43
Attorney, Agent or Firm:
LEE, Un Cheol (KR)
Download PDF: