Title:
METHOD OF PRODUCING 3-HYDROXYBUTYRALDEHYDE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2006/101092
Kind Code:
A1
Abstract:
A method of producing a 3-hydroxybutyraldehyde derivative, in particular, an optically active 3-hydroxybutyraldehyde derivative which is useful as an intermediate of drugs, etc. Namely, a method characterized by comprising converting a 3-hydroxybutyrate derivative into an alcohol derivative by a reduction reaction and then deriving it into the desired aldehyde derivative by an oxidation reaction with the use of a nitroxyl compound and a cooxidant. Thus, a 3-hydroxybutyraldehyde derivative having high qualities (containing only a small amount of a low alcohol derivative) can be produced by a convenient method without resorting to a reaction under an extremely low temperature conditions.
Inventors:
IZUMIDA MASASHI (JP)
MATSUMOTO SHINGO (JP)
MATSUMOTO SHINGO (JP)
Application Number:
PCT/JP2006/305598
Publication Date:
September 28, 2006
Filing Date:
March 20, 2006
Export Citation:
Assignee:
KANEKA CORP (JP)
IZUMIDA MASASHI (JP)
MATSUMOTO SHINGO (JP)
IZUMIDA MASASHI (JP)
MATSUMOTO SHINGO (JP)
International Classes:
C07F7/18; C07C45/27; C07C47/19; C07B53/00
Foreign References:
| JPS63233989A | 1988-09-29 |
Other References:
ERNST B. ET AL.: "Synthesis of the Oviposition-Deterring Pheromone (ODP) in Rhagoletis cerasi L", HELVETICA.CHIMICA.ACTA., vol. 72, no. 1, 1989, pages 165 - 171, XP001025818
MAEMOTO S. ET AL.: "Synthesis of (4R, 5S, 11R)-(-)-Cladospolide A, a Phytotoxic Macrolide from Cladosporium cladosporioides", CHEMISTRY LETTERS, no. 1, 1987, pages 109 - 122, XP003006749
INOKUCHI T. ET AL.: "A Selective and Efficient Method for Alcohol Oxidations Mediated by N-Oxoammonium Salts in Combination with Sodium Bromite", JOURNAL OF ORGANIC CHEMISTRY, vol. 55, no. 2, 1990, pages 462 - 466, XP000567758
SIEDLECKA R. ET AL.: "SELECTIVE OXIDATION OF PRIMARY HYDROXY GROUPS IN PRIMARY-SECONDARY DIOLS", TETRAHEDRON LETTERS, vol. 31, no. 15, 1990, pages 2177 - 2180, XP003006750
MAEMOTO S. ET AL.: "Synthesis of (4R, 5S, 11R)-(-)-Cladospolide A, a Phytotoxic Macrolide from Cladosporium cladosporioides", CHEMISTRY LETTERS, no. 1, 1987, pages 109 - 122, XP003006749
INOKUCHI T. ET AL.: "A Selective and Efficient Method for Alcohol Oxidations Mediated by N-Oxoammonium Salts in Combination with Sodium Bromite", JOURNAL OF ORGANIC CHEMISTRY, vol. 55, no. 2, 1990, pages 462 - 466, XP000567758
SIEDLECKA R. ET AL.: "SELECTIVE OXIDATION OF PRIMARY HYDROXY GROUPS IN PRIMARY-SECONDARY DIOLS", TETRAHEDRON LETTERS, vol. 31, no. 15, 1990, pages 2177 - 2180, XP003006750
Attorney, Agent or Firm:
KANEKA CORPORATION (Kita-ku Osaka-shi, Osaka 88, JP)
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