Title:
METHOD FOR PRODUCING ALDEHYDE
Document Type and Number:
WIPO Patent Application WO/2018/079705
Kind Code:
A1
Abstract:
A method is described for producing an objective substance, for example, an aldehyde such as vanillin. The objective substance is produced from a carbon source or a precursor of the objective substance by using a microorganism having an ability to produce the objective substance, wherein the microorganism has been modified to have a specific carboxylic acid reductase (CAR) gene, such as a Gordonia CAR gene, Novosphingobium CAR gene, or Coccomyxa CAR gene.
Inventors:
TOYAZAKI MIKU (JP)
FUKUI KEITA (JP)
FUKUI KEITA (JP)
Application Number:
PCT/JP2017/038875
Publication Date:
May 03, 2018
Filing Date:
October 27, 2017
Export Citation:
Assignee:
AJINOMOTO KK (JP)
International Classes:
C12N9/04
Domestic Patent References:
| WO2017073701A2 | 2017-05-04 | |||
| WO2015009558A1 | 2015-01-22 | |||
| WO2013022881A1 | 2013-02-14 | |||
| WO2013022881A1 | 2013-02-14 | |||
| WO2004111254A1 | 2004-12-23 | |||
| WO2013022881A1 | 2013-02-14 | |||
| WO2007046389A1 | 2007-04-26 | |||
| WO2013069634A1 | 2013-05-16 | |||
| WO2005010175A1 | 2005-02-03 |
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| US20040180400A1 | 2004-09-16 | |||
| JP2015535181A | 2015-12-10 | |||
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| EP0952221A2 | 1999-10-27 | |||
| JPH02109985A | 1990-04-23 | |||
| US5882888A | 1999-03-16 | |||
| EP0805867B1 | 2003-12-17 | |||
| JPH03210184A | 1991-09-13 | |||
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| JP2010207094A | 2010-09-24 | |||
| JPS5089592A | 1975-07-18 | |||
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CARTER P.: "Meth. In Enzymol.", vol. 154, 1987, pages: 382
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KUNKEL, T.A. ET AL., METH. IN ENZYMOL., vol. 154, 1987, pages 367
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M.T. CHAUDHRY ET AL., MICROBIOLOGY, vol. 153, 2007, pages 857 - 865
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HIGGINS ET AL., GENE, vol. 73, 1988, pages 237 - 244
HIGGINS ET AL., CABIOS, vol. 5, 1989, pages 151 - 153
CORPET ET AL., NUCLEIC ACIDS RES., vol. 16, 1988, pages 10881 - 10890
HUANG ET AL., CABIOS, vol. 8, 1992, pages 155 - 165
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 331
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389
MILLER, J.H.: "Experiments in Molecular Genetics", 1972, COLD SPRING HARBOR LABORATORY
DATSENKO, K.A.; WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
AGRIC. BIOL. CHEM., vol. 48, 1984, pages 2901 - 2903
"Fundamental Microbiology Vol. 8, Genetic Engineering", vol. 8, 1987, KYORITSU SHUPPAN CO., LTD
GENE, vol. 60, no. 1, 1987, pages 115 - 127
CARTER, P., METH. IN ENZYMOL., vol. 154, 1987, pages 382
APPL. MICROBIOL. BIOTECHNOL., vol. 53, 2000, pages 674 - 679
JOURNAL OF BIOTECHNOLOGY, vol. 104, 2003, pages 311 - 323
APPL. ENVIRON. MICROBIOL., vol. 71, no. 12, December 2005 (2005-12-01), pages 8587 - 8596
GOLDSTEIN ET AL., PROKARYOTIC PROMOTERS IN BIOTECHNOLOGY, BIOTECHNOL. ANNU. REV., vol. 1, 1995, pages 105 - 128
OLINS P.O. ET AL., GENE, vol. 73, 1988, pages 227 - 235
NAKAMURA, Y. ET AL., NUCL. ACIDS RES., vol. 28, 2000, pages 292
MANDEL, M.; HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159 - 162
DUNCAN, C.H.; WILSON, G.A.; YOUNG, F.E., GENE, vol. 1, 1977, pages 153 - 167
CHANG, S.; CHOEN, S.N., MOL. GEN. GENET., vol. 168, 1979, pages 111 - 115
BIBB, M.J.; WARD, J.M.; HOPWOOD, O.A., NATURE, vol. 274, 1978, pages 398 - 400
HINNEN, A.; HICKS, J.B.; FINK, G.R., PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929 - 1933
SAMBROOK, J. ET AL.: "Molecular Cloning A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
"Molecular Cloning", 2001, COLD SPRING HARBOR LABORATORY PRESS
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, 1997, pages 8611 - 8617
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 95, 1998, pages 5511 - 5515
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 26, no. 116, 1991, pages 20833 - 20839
DATSENKO, K.A; WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
CHO, E.H.; GUMPORT, R.I.; GARDNER, J.F., J. BACTERIOL., vol. 184, 2002, pages 5200 - 5203
J. AM. CHM. SOC., vol. 120, 1998
J. APP. MICROBIOL., vol. 116, 2013, pages 903 - 910
HORI, H. ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 48, no. 6, 1997, pages 693 - 698
YAMAMOTO, S ET AL., BIOSCI. BIOTECHNOL. BIOCHEM., vol. 69, no. 4, 2005, pages 784 - 789
C. AUG'E; CH. GAUTHERON, TETRAHEDRON LETT., vol. 29, 1988, pages 789 - 790
MURATA, K. ET AL., AGRIC. BIOL. CHEM., vol. 52, no. 6, 1988, pages 1471 - 1477
"Current Microbiology", vol. 51, 2005, pages: 59 - 65
BACKMANN B.J.: "Escherichia coli and Salmonella Cellular and Molecular Biology", 1996, AMERICAN SOCIETY FOR MICROBIOLOGY PRESS, article "Derivations and Genotypes of some mutant derivatives of Escherichia coli K-12", pages: 2460 - 2488
BIOTECHNOL. BIOENG., vol. 98, no. 2, 27 March 2007 (2007-03-27), pages 340 - 348
INT. J. SYST. BACTERIOL., vol. 39, 1989, pages 337 - 345
INT. J. SYST. BACTERIOL., vol. 43, 1993, pages 162 - 173
INT. J. SYST. BACTERIOL., vol. 41, 1991, pages 255
INT. J. SYST. EVOL. MICROBIOL., vol. 60, 2010, pages 874 - 879
DATABASE GenBank [O] retrieved from ncbi Database accession no. NP _000745
DATABASE GenBank [O] retrieved from ncbi Database accession no. NP_009294
DATABASE GenBank [O] retrieved from ncbi Database accession no. NP_200227
DATABASE GenBank [O] retrieved from ncbi Database accession no. AAF28353
DATABASE GenBank [O] retrieved from ncbi Database accession no. NM_000754.3
DATABASE GenBank [O] retrieved from ncbi Database accession no. NM_001135161.1
DATABASE GenBank [O] retrieved from ncbi Database accession no. NM_001135162.1
DATABASE GenBank [O] retrieved from ncbi Database accession no. NM_007310.2
ELIZABETH C. TYLER ET AL., COMPUTERS AND BIOMEDICAL RESEARCH, vol. 24, no. 1, 1991, pages 72 - 96
BARTON GJ ET AL., JOURNAL OF MOLECULAR BIOLOGY, vol. 198, no. 2, 1987, pages 327 - 337
"PCR Technology", 1989, STOCKTON PRESS
CARTER P.: "Meth. In Enzymol.", vol. 154, 1987, pages: 382
KRAMER, W.; FRITS, H.J., METH. IN ENZYMOL., vol. 154, 1987, pages 350
KUNKEL, T.A. ET AL., METH. IN ENZYMOL., vol. 154, 1987, pages 367
J. BIOL. CHEM., vol. 282, no. 1, 2007, pages 478 - 485
APP. ENV. MICROBIOL., vol. 75, no. 9, 2009, pages 2765 - 2774
M.T. CHAUDHRY ET AL., MICROBIOLOGY, vol. 153, 2007, pages 857 - 865
M. T. CHAUDHRY ET AL., MICROBIOLOGY, vol. 153, 2007, pages 857 - 865
CURRENT MICROBIOLOGY, vol. 51, 2005, pages 59 - 65
APPL. MICROBIOL. BIOTECHNOL., vol. 95, 2012, pages 77 - 89
KUNJAPUR AM ET AL., J. AM. CHEM. SOC., vol. 136, 2014, pages 11644 - 11654
HANSEN EH. ET AL., APP. ENV. MICROBIOL., vol. 75, 2009, pages 2765 - 2774
J BACTERIOL, vol. 183, 2001, pages 3276 - 3281
METH. ENZ., vol. l7A, 1970, pages 526 - 529
MYERS; MILLER, CABIOS, vol. 4, 1988, pages 11 - 17
SMITH ET AL., ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMAN; WUNSCH, J. MOL. BIOL., vol. 48, 1970, pages 443 - 453
PEARSON; LIPMAN, PROC. NATL. ACAD. SCI., vol. 85, 1988, pages 2444 - 2448
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 87, 1990, pages 2264
KARLIN; ALTSCHUL, PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 5873 - 5877
HIGGINS ET AL., GENE, vol. 73, 1988, pages 237 - 244
HIGGINS ET AL., CABIOS, vol. 5, 1989, pages 151 - 153
CORPET ET AL., NUCLEIC ACIDS RES., vol. 16, 1988, pages 10881 - 10890
HUANG ET AL., CABIOS, vol. 8, 1992, pages 155 - 165
PEARSON ET AL., METH. MOL. BIOL., vol. 24, 1994, pages 307 - 331
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389
MILLER, J.H.: "Experiments in Molecular Genetics", 1972, COLD SPRING HARBOR LABORATORY
DATSENKO, K.A.; WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
AGRIC. BIOL. CHEM., vol. 48, 1984, pages 2901 - 2903
"Fundamental Microbiology Vol. 8, Genetic Engineering", vol. 8, 1987, KYORITSU SHUPPAN CO., LTD
GENE, vol. 60, no. 1, 1987, pages 115 - 127
CARTER, P., METH. IN ENZYMOL., vol. 154, 1987, pages 382
APPL. MICROBIOL. BIOTECHNOL., vol. 53, 2000, pages 674 - 679
JOURNAL OF BIOTECHNOLOGY, vol. 104, 2003, pages 311 - 323
APPL. ENVIRON. MICROBIOL., vol. 71, no. 12, December 2005 (2005-12-01), pages 8587 - 8596
GOLDSTEIN ET AL., PROKARYOTIC PROMOTERS IN BIOTECHNOLOGY, BIOTECHNOL. ANNU. REV., vol. 1, 1995, pages 105 - 128
OLINS P.O. ET AL., GENE, vol. 73, 1988, pages 227 - 235
NAKAMURA, Y. ET AL., NUCL. ACIDS RES., vol. 28, 2000, pages 292
MANDEL, M.; HIGA, A., J. MOL. BIOL., vol. 53, 1970, pages 159 - 162
DUNCAN, C.H.; WILSON, G.A.; YOUNG, F.E., GENE, vol. 1, 1977, pages 153 - 167
CHANG, S.; CHOEN, S.N., MOL. GEN. GENET., vol. 168, 1979, pages 111 - 115
BIBB, M.J.; WARD, J.M.; HOPWOOD, O.A., NATURE, vol. 274, 1978, pages 398 - 400
HINNEN, A.; HICKS, J.B.; FINK, G.R., PROC. NATL. ACAD. SCI. USA, vol. 75, 1978, pages 1929 - 1933
SAMBROOK, J. ET AL.: "Molecular Cloning A Laboratory Manual", 2001, COLD SPRING HARBOR LABORATORY PRESS
"Molecular Cloning", 2001, COLD SPRING HARBOR LABORATORY PRESS
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, 1997, pages 8611 - 8617
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, USA, vol. 95, 1998, pages 5511 - 5515
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 26, no. 116, 1991, pages 20833 - 20839
DATSENKO, K.A; WANNER, B.L., PROC. NATL. ACAD. SCI. USA, vol. 97, 2000, pages 6640 - 6645
CHO, E.H.; GUMPORT, R.I.; GARDNER, J.F., J. BACTERIOL., vol. 184, 2002, pages 5200 - 5203
J. AM. CHM. SOC., vol. 120, 1998
J. APP. MICROBIOL., vol. 116, 2013, pages 903 - 910
HORI, H. ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 48, no. 6, 1997, pages 693 - 698
YAMAMOTO, S ET AL., BIOSCI. BIOTECHNOL. BIOCHEM., vol. 69, no. 4, 2005, pages 784 - 789
C. AUG'E; CH. GAUTHERON, TETRAHEDRON LETT., vol. 29, 1988, pages 789 - 790
MURATA, K. ET AL., AGRIC. BIOL. CHEM., vol. 52, no. 6, 1988, pages 1471 - 1477
"Current Microbiology", vol. 51, 2005, pages: 59 - 65
Attorney, Agent or Firm:
KAWAGUCHI, Yoshiyuki et al. (JP)
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