Title:
METHOD FOR PRODUCING ALPHA-METHYLATED CYSTEINE AND SERINE DERIVATIVES
Document Type and Number:
WIPO Patent Application WO2004092119
Kind Code:
A3
Abstract:
The invention relates to an improved method for the production, purification and crystallisation of alpha -methylated cysteine or serine derivatives by an acid hydrolysis of corresponding thiazolidine or oxazolidine esters, with the continuous removal of the accumulating aldehyde, a prior optional conversion into a thiazolidine or oxazolidine carboxylic acid or a thiazolidine or oxazolidine carboxylate and a subsequent azeotropic distillation.
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Inventors:
HELDMANN DIETER (DE)
STOHRER JUERGEN (DE)
STOHRER JUERGEN (DE)
Application Number:
PCT/EP2004/003777
Publication Date:
March 03, 2005
Filing Date:
April 08, 2004
Export Citation:
Assignee:
CONSORTIUM ELEKTROCHEM IND (DE)
HELDMANN DIETER (DE)
STOHRER JUERGEN (DE)
HELDMANN DIETER (DE)
STOHRER JUERGEN (DE)
International Classes:
C07C227/14; C07C227/32; C07C319/02; C07D263/06; C07D277/06; C12P13/06; C12P13/12; C07C229/22; C07C323/58; C07D; (IPC1-7): C12P13/06; C12P13/12
Foreign References:
| EP0662481A1 | 1995-07-12 | |||
| EP1302467A2 | 2003-04-16 |
Other References:
MULQUEEN, GERARD C. ET AL: "Synthesis of the thiazoline-based siderophore (S)-desferrithiocin", TETRAHEDRON , 49(24), 5359-64 CODEN: TETRAB; ISSN: 0040-4020, 1993, XP001119496
PATTENDEN, GERALD ET AL: "Enantioselective synthesis of 2-alkyl substituted cysteines", TETRAHEDRON , 49(10), 2131-8 CODEN: TETRAB; ISSN: 0040-4020, 1993, XP002174899
SEEBACH, DIETER ET AL: "Stereoselective alkylation at C(.alpha.) of serine, glyceric acid, threonine, and tartaric acid involving heterocyclic enolates with exocyclic double bonds", HELVETICA CHIMICA ACTA , 70(4), 1194-216 CODEN: HCACAV; ISSN: 0018-019X, 1987, XP002213547
SEEBACH, DIETER ET AL: ".alpha.-Alkylation of serine with self-reproduction of the center of chirality", TETRAHEDRON LETTERS , 25(24), 2545-8 CODEN: TELEAY; ISSN: 0040-4039, 1984, XP002290067
PATTENDEN, GERALD ET AL: "Enantioselective synthesis of 2-alkyl substituted cysteines", TETRAHEDRON , 49(10), 2131-8 CODEN: TETRAB; ISSN: 0040-4020, 1993, XP002174899
SEEBACH, DIETER ET AL: "Stereoselective alkylation at C(.alpha.) of serine, glyceric acid, threonine, and tartaric acid involving heterocyclic enolates with exocyclic double bonds", HELVETICA CHIMICA ACTA , 70(4), 1194-216 CODEN: HCACAV; ISSN: 0018-019X, 1987, XP002213547
SEEBACH, DIETER ET AL: ".alpha.-Alkylation of serine with self-reproduction of the center of chirality", TETRAHEDRON LETTERS , 25(24), 2545-8 CODEN: TELEAY; ISSN: 0040-4039, 1984, XP002290067
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