Title:
METHOD FOR PRODUCING AMINO ACID AND PEPTIDE COMPOUND, USING ENZYME AND ADDITIVE
Document Type and Number:
WIPO Patent Application WO/2023/219156
Kind Code:
A1
Abstract:
One aspect of the present invention pertains to a method for producing an amino acid, the method comprising a step for conducting a reaction of (i) or (ii), in the presence of a compound D represented by formula (1), a reducing agent, and a polypeptide having an amino acid sequence that has an identity of 90% or more with respect to the amino acid sequence represented by SEQ ID NO. 1. (i) An intermolecular reductive amination reaction between: a compound A selected from the group consisting of compounds having an amino group and salts thereof; and a compound B selected from the group consisting of compounds having a carbonyl group and salts thereof. (ii) An intramolecular reductive amination reaction of a compound C selected from the group consisting of compounds having an amino group and a carbonyl group, and salts thereof.
Inventors:
ISHIYAMA SHIORI (JP)
NAKANO KAZUHIKO (SG)
SHINODA KIYOMICHI (JP)
NAKANO KAZUHIKO (SG)
SHINODA KIYOMICHI (JP)
Application Number:
PCT/JP2023/017861
Publication Date:
November 16, 2023
Filing Date:
May 12, 2023
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C12N15/53; C07C227/28; C07C229/12; C07K1/00; C12N9/06; C12N15/31; C12P13/04
Domestic Patent References:
| WO2003072770A1 | 2003-09-04 |
Foreign References:
| JP2005095167A | 2005-04-14 |
Other References:
MINDT MELANIE, HANNIBAL SILVIN, HEUSER MARIA, RISSE JOE MAX, SASIKUMAR KEERTHI, NAMPOOTHIRI K. MADHAVAN, WENDISCH VOLKER F.: "Fermentative Production of N-Alkylated Glycine Derivatives by Recombinant Corynebacterium glutamicum Using a Mutant of Imine Reductase DpkA From Pseudomonas putida", FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, vol. 7, 26 September 2019 (2019-09-26), XP093041951, DOI: 10.3389/fbioe.2019.00232
Attorney, Agent or Firm:
HASEGAWA Yoshiki et al. (JP)
Download PDF: