Title:
METHOD FOR PRODUCING COMPOUND OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/058645
Kind Code:
A1
Abstract:
Provided is a technique for improving the productivity in a method for producing a compound I or a pharmaceutically acceptable salt thereof. This method for producing the compound I has: a step for preparing a compound 16 solution by deprotecting a compound 10-R3 in a solvent; and a step for adding a compound 15 to the compound 16 solution without isolating the compound 16 and synthesizing the compound I in the presence of a condensing agent.
Inventors:
MINAMIKAWA RYO (JP)
MATSUTANI AKIRA (JP)
MAGATA YUYA (JP)
KAWANISHI SHINJI (JP)
KAWAHIRA MIZUKI (JP)
MATSUTANI AKIRA (JP)
MAGATA YUYA (JP)
KAWANISHI SHINJI (JP)
KAWAHIRA MIZUKI (JP)
Application Number:
PCT/JP2022/037098
Publication Date:
April 13, 2023
Filing Date:
October 04, 2022
Export Citation:
Assignee:
EA PHARMA CO LTD (JP)
International Classes:
C07D401/04; A61K31/63; C07D213/40
Domestic Patent References:
| WO2017135472A1 | 2017-08-10 | |||
| WO2017135471A1 | 2017-08-10 |
Foreign References:
| JP2019031449A | 2019-02-28 |
Other References:
芦澤 一英, KAZUHIDE ASHIZAWA: "芦澤 一英, 塩･結晶形の最適化と結晶化技術. Optimization of salt and crystal forms and crystallization technolog", PHARM TECH JAPAN., vol. 18, no. 10, 2022, pages 81 - 96
ASHIZAWA, KAZUHID, TOYOKURA, KEN: "The Science of Pharmaceutical Polymorphism and Crystallization : Trends in Development/Manufacturing and Regulation", 2002, MARUZEN PLANET CO., LTD., article "Polymorphism and crystallization of the pharmaceutical drugs", pages: 305 - 317
平山 令明. HIRAYAMA, NORIAKI: "有機化合物結晶作製ハンドブック -原理とノウハウ- Handbook of Organic Compound Crystal Preparation -Principles and Know-how-", 2008, article "(3. Common Techniques for Crystallization", pages: 36 - 43
YALE H. L., SPITZMILLER E. R.: "6- AND 7-SUBSTITUTED 4H-PYRIDOÚA,2-A¾PYRIMIDIN-4-ONES SYNTHESIS VIATHE ACID-CATALYZED ISOMERIZATION OF 2-(ACETOACETAMIDO)PYRIDINES (1)", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 14., no. 04., 1 June 1977 (1977-06-01), US , pages 637 - 646., XP000562847, ISSN: 0022-152X, DOI: 10.1002/jhet.5570140420
ASHIZAWA, KAZUHID, TOYOKURA, KEN: "The Science of Pharmaceutical Polymorphism and Crystallization : Trends in Development/Manufacturing and Regulation", 2002, MARUZEN PLANET CO., LTD., article "Polymorphism and crystallization of the pharmaceutical drugs", pages: 305 - 317
平山 令明. HIRAYAMA, NORIAKI: "有機化合物結晶作製ハンドブック -原理とノウハウ- Handbook of Organic Compound Crystal Preparation -Principles and Know-how-", 2008, article "(3. Common Techniques for Crystallization", pages: 36 - 43
YALE H. L., SPITZMILLER E. R.: "6- AND 7-SUBSTITUTED 4H-PYRIDOÚA,2-A¾PYRIMIDIN-4-ONES SYNTHESIS VIATHE ACID-CATALYZED ISOMERIZATION OF 2-(ACETOACETAMIDO)PYRIDINES (1)", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC., US, vol. 14., no. 04., 1 June 1977 (1977-06-01), US , pages 637 - 646., XP000562847, ISSN: 0022-152X, DOI: 10.1002/jhet.5570140420
Attorney, Agent or Firm:
TANAKA Shinichiro et al. (JP)
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