Title:
METHOD FOR PRODUCING DIHYDROPYRIDAZINE-3,5-DIONE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2022/260062
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a method that is for producing p-toluenesulfonate of 7-(2,3-difluoro-4-(2-((2-methoxyethyl)(methyl)amino)ethoxy)benzyl)-10-hydroxy-6-methy-N-(4-methyl-2-(6-methylpyrimidine-4-yl)phenyl)-8-oxo-6,7-diazaspiro[4.5]deca-9-en-9-carboxamide which is industrially preferable and that makes it possible to obtain a target product more easily and more inexpensively than conventional methods. For the present invention, a method was found which makes it possible to efficiently obtain a target product via a step for obtaining a wet powder of p-toluenesulfonate of 7-(2,3-difluoro-4-(2-((2-methoxyethyl)(methyl)amino)ethoxy)benzyl)-10-hydroxy-6-methy-N-(4-methyl-2-(6-methylpyrimidine-4-yl)phenyl)-8-oxo-6,7-diazaspiro[4.5]deca-9-en-9-carboxamide and also a step for drying the wet powder.
Inventors:
MURAKATA MASATOSHI (JP)
KOMIYA SHIO (JP)
HOU ZENGYE (JP)
ENOMOTO TARO (JP)
TANIDA SATOSHI (JP)
FUKUDA HIROSHI (JP)
KOMIYA SHIO (JP)
HOU ZENGYE (JP)
ENOMOTO TARO (JP)
TANIDA SATOSHI (JP)
FUKUDA HIROSHI (JP)
Application Number:
PCT/JP2022/023068
Publication Date:
December 15, 2022
Filing Date:
June 08, 2022
Export Citation:
Assignee:
CHUGAI PHARMACEUTICAL CO LTD (JP)
International Classes:
C07D403/12; A61K31/506; A61P3/00; A61P13/12
Domestic Patent References:
WO2014142273A1 | 2014-09-18 | |||
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Foreign References:
JP2017501666A | 2017-01-12 |
Other References:
TSUBOI YOSHINORI, OHTOMO SHUICHI, ICHIDA YASUHIRO, HAGITA HITOSHI, OZAWA KAZUHARU, IIDA MANAMI, NAGAO SHUNSUKE, IKEGAMI HISASHI, T: "EOS789, a novel pan-phosphate transporter inhibitor, is effective for the treatment of chronic kidney disease-mineral bone disorder", KIDNEY INTERNATIONAL, vol. 98, no. 2, 23 April 2020 (2020-04-23), pages 343 - 354, XP093014269, DOI: 10.1016/j.kint.2020.02.040
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HRUSKA, KA ET AL., KIDNEY INT., vol. 74, no. 2, 2008, pages 148 - 157
"Definition and classification of CKD", KIDNEY INT. SUPPL., vol. 3, no. 1, 2013, pages 19 - 62
LEVEY, AS ET AL., KIDNEY INT., vol. 67, no. 6, 2005, pages 2089 - 2100
RITTER, CS ET AL., CLIN. J.AM.SOC.NEPHROL, vol. 11, no. 6, 2016, pages 1088 - 1100
MIYAMOTO, K ET AL., J. PHARM. SCI., vol. 100, no. 9, 2011, pages 3719 - 3730
SABBAGH, Y ET AL., J. AM. SOC. NEPHROL., vol. 20, no. 11, 2009, pages 2348 - 2358
FORSTER IC ET AL., MOL ASPECTS MED., vol. 34, no. 2-3, 2013, pages 386 - 395
LEDERER E ET AL., EUR. J. PHYSIOL., vol. 471, no. 1, 2019, pages 137 - 148
VIJAYALAKSHMI C ET AL., LETT. ORG. CHEM., vol. 17, no. 1, 2020, pages 68 - 72
JOURNAL OF TECHNICAL DISCLOSURE, TECHNIQUE, no. 2017-501666
CHEMBURKAR SR ET AL., ORG. PROC. RES. DEV., vol. 4, no. 5, 2000, pages 413 - 417
WILLIAMSON, AW ET AL., J. CHEM. SOC, no. 106, 8 January 1952 (1952-01-08), pages 229 - 239
Attorney, Agent or Firm:
YAMAMOTO, Osamu et al. (JP)
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