Title:
METHOD FOR PRODUCING ECTOINE
Document Type and Number:
WIPO Patent Application WO/2024/058311
Kind Code:
A1
Abstract:
The present invention relates to a method for producing ectoine, the method being charcteriezed by comprising: a step for producing (2-nosyl)-L-glutamine by introducing a nosyl group into L-glutamine as a protecting group; a step for producing (S)-4-amino-(2-nosyl)butanoic acid from said compound through a Hoffman rearrangement reaction; a step for preparing (S)-2,4-diaminobutanoic acid by removing (deprotection of) the nosyl group; and a step for carrying out a cyclization reaction in an alcohol solvent in the presence of an organic/inorganic base to finally obtain ectoine.
Inventors:
KIM HYOUNG SHIK (KR)
LEE CHUNG RYUL (KR)
PARK TAE EUN (KR)
KIM CHANG GON (KR)
JU HYO JUNG (KR)
LEE CHUNG RYUL (KR)
PARK TAE EUN (KR)
KIM CHANG GON (KR)
JU HYO JUNG (KR)
Application Number:
PCT/KR2022/019433
Publication Date:
March 21, 2024
Filing Date:
December 01, 2022
Export Citation:
Assignee:
KIM HYOUNG SHIK (KR)
International Classes:
C07D239/06
Domestic Patent References:
| WO1998024461A1 | 1998-06-11 |
Foreign References:
| CN106916111A | 2017-07-04 | |||
| EP3854786A1 | 2021-07-28 | |||
| CN111471019A | 2020-07-31 |
Other References:
KUROSAWA, WATARU, TOSHIYUKI KAN, AND TOHRU FUKUYAMA: "PREPARATION OF SECONDARY AMINES FROM PRIMARY AMINES VIA 2-NITROBENZENESULFONAMIDES: N-(4-METHOXYBENZYL)-3-PHENYLPROPYLAMINE", ORGANIC SYNTHESES, WILEY AND SONS, NEW YORK, NY., US, vol. 79, 1 January 2002 (2002-01-01), US , pages 186 - 191, XP093146002, ISSN: 0078-6209, DOI: 10.15227/orgsyn.079.0186
Attorney, Agent or Firm:
KIM, Hyun Jin (KR)
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