Title:
METHOD FOR PRODUCING FLUORINATED COMPOUND
Document Type and Number:
WIPO Patent Application WO/2017/154948
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a novel method for producing a compound having a fluoromethylene group with high efficiency.
The problem can be solved by a method for producing a compound represented by formula (1) [wherein R1 represents an organic group; RX represents a hydrogen atom or a fluorine atom; R2a, R2b, R2c and R2d may be the same as or different from one another and independently represent -Y-R21 or -N(-R22)2, or R2b and R2c may be lined to each other to form a bond; Y represents a bond, an oxygen atom or a sulfur atom; R21 represents a hydrogen atom or an organic group; and R22's may be the same as or different from each other in every event, and independently represent a hydrogen atom or an organic group], a ring-closed or ring-opened derivative of the compound, said method comprising step A of reacting a compound represented by formula (2) [wherein X represents a leaving group; and other symbols are as defined above] with a compound represented by formula (3) [wherein the symbols are as defined above] in the presence of a reducing agent under the irradiation with light.
Inventors:
MATSUURA MAKOTO (JP)
YAMAMOTO AKINORI (JP)
KISHIKAWA YOSUKE (JP)
RYU ILHYONG (JP)
FUKUYAMA TAKAHIDE (JP)
SUMINO SHUHEI (JP)
YAMAMOTO AKINORI (JP)
KISHIKAWA YOSUKE (JP)
RYU ILHYONG (JP)
FUKUYAMA TAKAHIDE (JP)
SUMINO SHUHEI (JP)
Application Number:
PCT/JP2017/009144
Publication Date:
September 14, 2017
Filing Date:
March 08, 2017
Export Citation:
Assignee:
DAIKIN IND LTD (JP)
UNIV OSAKA PREFECT PUBLIC CORP (JP)
UNIV OSAKA PREFECT PUBLIC CORP (JP)
International Classes:
C07C17/275; C07C19/08; C07C22/08; C07C41/30; C07C43/174; C07C67/343; C07C69/24; C07C69/608; C07C69/612; C07C69/675; C07B37/02; C07B61/00
Other References:
CHUNGHYEON YU ET AL.: "Selective difluoroalkylation of alkenes by using visible light photoredox ctalysis", CHEMICAL COMMUNICATIONS, vol. 50, 2014, pages 12884 - 12887, XP055420801
SHUHEI SUMINO ET AL.: "Reductiv Bromine Arom- Transfer Reaction", ORGANIC LETTERS, vol. 15, no. 11, 2013, pages 2826 - 2829, XP055420803
SHUHEI SUMINO ET AL.: "Hydroalkylation of Alkenes Using Alkyl Iodides and Hantzsch Ester under Palladium/Light System", ORGANIC LETTERS, vol. 18, 21 December 2015 (2015-12-21), pages 52 - 55, XP055420805
R. STEPHEN ANDREWS ET AL.: "Intermolecular Addition of Glycosyl Halides to Alkenes Mediated by Visible Light", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 49, 2010, pages 7274 - 7276, XP055420806
TOMOKO YAJIMA ET AL.: "Photoinduced radical hydroperfluoroalkylation and the synthesis of fluorinated amino acids and peptides", JOURNAL OF FLUORINE CHEMISTRY, vol. 150, 2013, pages 1 - 7, XP028585123
SHUHEI SUMINO ET AL.: "Reductiv Bromine Arom- Transfer Reaction", ORGANIC LETTERS, vol. 15, no. 11, 2013, pages 2826 - 2829, XP055420803
SHUHEI SUMINO ET AL.: "Hydroalkylation of Alkenes Using Alkyl Iodides and Hantzsch Ester under Palladium/Light System", ORGANIC LETTERS, vol. 18, 21 December 2015 (2015-12-21), pages 52 - 55, XP055420805
R. STEPHEN ANDREWS ET AL.: "Intermolecular Addition of Glycosyl Halides to Alkenes Mediated by Visible Light", ANGEWANDTE CHEMIE INTERNATIONAL EDITION, vol. 49, 2010, pages 7274 - 7276, XP055420806
TOMOKO YAJIMA ET AL.: "Photoinduced radical hydroperfluoroalkylation and the synthesis of fluorinated amino acids and peptides", JOURNAL OF FLUORINE CHEMISTRY, vol. 150, 2013, pages 1 - 7, XP028585123
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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