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Title:
METHOD FOR PRODUCING HEPARAN SULFATE HAVING ANTICOAGULANT ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2017/115674
Kind Code:
A1
Abstract:
Provided is a method for producing heparan sulfate having anticoagulant activity. More specifically, provided is a method for producing heparan sulfate having a desired average molecular weight, said method comprising partially N-deacetylating heparosan, then degrading the same by treating with heparinase III, and converting the low-molecular compound thus obtained into heparan sulfate having anticoagulant activity.

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Inventors:
TOKURA YURIKO (JP)
Application Number:
PCT/JP2016/087688
Publication Date:
July 06, 2017
Filing Date:
December 16, 2016
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Assignee:
AJINOMOTO KK (JP)
International Classes:
C12P19/04; C08B37/10; A61K31/727; A61P7/02; C12N9/14; C12N15/09
Domestic Patent References:
WO2015050184A12015-04-09
WO2004050673A22004-06-17
Foreign References:
JP2008512105A2008-04-24
JP2007501305A2007-01-25
JP2007517771A2007-07-05
Other References:
CHAI, WENGANG ET AL.: "Relative Susceptibilities of the Glucosamine-Glucuronic Acid and N-Acetylglucosamine-Glucuronic Acid Linkages to Heparin Lyase III", BIOCHEMISTRY, vol. 43, no. 26, 2004, pages 8590 - 8599, XP055396250
Attorney, Agent or Firm:
SAKAI INTERNATIONAL PATENT OFFICE (JP)
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