Title:
METHOD FOR PRODUCING IBUPROFEN BY MEANS OF MULTISTAGE CONTINUOUS REACTION CRYSTALLIZATION
Document Type and Number:
WIPO Patent Application WO/2021/073099
Kind Code:
A1
Abstract:
Disclosed is a continuous crystallization process for ibuprofen, wherein an ibuprofen product is obtained by means of multistage continuous crystallization; and the multistage continuous reaction crystallization comprises the steps of reaction to form an oil, two to four stages of reaction crystallization, dehydration and washing, and the adjustments of pH and temperature of each step. The method effectively resolves the explosive nucleation phenomenon caused by oil analysis during the reaction crystallization of ibuprofen, has stable crystallization process conditions and simple operation control, and reduces pollution of the environment by using water as a solvent; and the resulting ibuprofen crystals have large and uniform particle size, and high product purity and yield. The method improves the stability and product quality of operation of the crystallization process, reduces the production cost, and achieves the stabilized industrial production of ibuprofen.
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Inventors:
DU DEPING (CN)
ZHOU LING (CN)
KOU ZUXING (CN)
ZHANG MEIJING (CN)
SUN KE (CN)
XIA BINGKUN (CN)
GUO FAZHI (CN)
ZHANG LING (CN)
ZHOU LING (CN)
KOU ZUXING (CN)
ZHANG MEIJING (CN)
SUN KE (CN)
XIA BINGKUN (CN)
GUO FAZHI (CN)
ZHANG LING (CN)
Application Number:
PCT/CN2020/092189
Publication Date:
April 22, 2021
Filing Date:
May 26, 2020
Export Citation:
Assignee:
SHANDONG XINHUA PHARMACEUTICAL (CN)
International Classes:
C07C51/43; C07C51/02; C07C57/30
Foreign References:
| CN110627629A | 2019-12-31 | |||
| JP2001335531A | 2001-12-04 | |||
| CN104193614A | 2014-12-10 | |||
| CN102320954A | 2012-01-18 | |||
| CN102311335A | 2012-01-11 | |||
| CN1585630A | 2005-02-23 | |||
| CN1314336A | 2001-09-26 |
Attorney, Agent or Firm:
QINGDAO FIRST PATENT & TRADEMARK AGENT CO., LTD. (CN)
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