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Title:
METHOD FOR PRODUCING MORPHINAN DERIVATIVES
Document Type and Number:
WIPO Patent Application WO/2019/189749
Kind Code:
A1
Abstract:
A method for producing compounds represented by the following general formula through a dealkylation reaction in which a boron trifluoride complex is used (in the formula, R1 is a C1-10 alkyl group, etc., R2 is a C1-10 alkyl group, etc., R3 is a hydrogen atom, etc., R4 is a hydrogen atom, etc., R5 and R6 are the same or different and are hydrogen atoms, etc., R7 and R8 are the same or different and are hydrogen atoms, etc., R9, R10, R11 are the same or different and are hydrogen atoms, C1-10 alkyl groups, etc., and R12 is a -C(=O)OR13 group, a -C(=O)-R14 group, a -C(O=)NR20R21 group, etc.).

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Inventors:
HIROSE MASAAKI (JP)
Application Number:
PCT/JP2019/013973
Publication Date:
October 03, 2019
Filing Date:
March 29, 2019
Export Citation:
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Assignee:
NIPPON CHEMIPHAR CO (JP)
International Classes:
C07D489/12
Domestic Patent References:
WO1998043978A11998-10-08
WO2013035833A12013-03-14
Foreign References:
JP2013543488A2013-12-05
JP2016504346A2016-02-12
JPS4954390A1974-05-27
US4891377A1990-01-02
Other References:
BENTLEY, K. W. ET AL.: "Novel analgesics and molecular rearrangements in the morphine-thebaine group. III. Alcohols of the 6,14-endo-ethenotetrahydrooripavine series and derived analogs of N-allylnormorphine and -norcodeine", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 89, no. 13, 1967, pages 3281 - 3292, XP002549410, ISSN: 0002-7863, doi:10.1021/ja00989a032
NODE, MANABU ET AL.: "Demethylation of Aliphatic Methyl Ethers with a Thiol and Boron Trifluoride", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS I, no. 20, 1976, pages 2237 - 2240, XP055638466
Attorney, Agent or Firm:
TANAI Sumio et al. (JP)
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