Title:
METHOD FOR PRODUCING NUCLEIC ACID MOLECULE, BIOMATERIAL, AND METHOD FOR PRODUCING BIOMATERIAL
Document Type and Number:
WIPO Patent Application WO/2021/084782
Kind Code:
A1
Abstract:
The present invention provides a method for producing a nucleic acid molecule that can obtain a nucleic acid molecule that binds to a target and does not inhibit a function of the target. The production method for a nucleic acid molecule of the present invention is a method for producing a nucleic acid molecule that binds to a first biological molecule and does not inhibit a function of the first biological molecule, the method including the steps of: (A) bringing a candidate nucleic acid molecule into contact with the first biological molecule to select a nucleic acid molecule that has bound to the first biological molecule as a first selected nucleic acid molecule; and (B) selecting the first selected nucleic acid molecule as an intended nucleic acid molecule.
Inventors:
FUJITA TOMOKO (JP)
WAGA IWAO (JP)
HORII KATSUNORI (JP)
STANTON MARTIN (US)
DALBY ANDREW (US)
WAGA IWAO (JP)
HORII KATSUNORI (JP)
STANTON MARTIN (US)
DALBY ANDREW (US)
Application Number:
PCT/JP2020/018142
Publication Date:
May 06, 2021
Filing Date:
April 28, 2020
Export Citation:
Assignee:
NEC SOLUTION INNOVATORS LTD (JP)
MOSAIC BIOSCIENCES INC (US)
MOSAIC BIOSCIENCES INC (US)
International Classes:
C12N15/115
Domestic Patent References:
| WO2014128289A1 | 2014-08-28 |
Other References:
YUKI MORISHITA: "2016 Fiscal Year Annual Research Report", pages 1 - 2, XP055807982, Retrieved from the Internet
MORISHITA Y., e al., 39th annual meeting abstract of Japan Society for Biomaterials, 2017.11.13, vol. 39, p. 157 (1P-103-I) whole abstract
ENAM SYED FAAIZ; KRIEGER JACK R.; SAXENA TARUN; WATTS BRIAN E.; OLINGY CLAIRE E.; BOTCHWEY EDWARD A.; BELLAMKONDA RAVI V.: "Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels", BIOMATERIALS, vol. 142, 10 July 2017 (2017-07-10), pages 52 - 61, XP085147120, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.07.013
JOON-HAW LEE , MARCELLA D CANNY , ANDREA DE ERKENEZ , DOMINIK KRILLEKE , YIN-SHAN NG , DAVID T SHIMA , ARTHUR PARDI , FIONA JUCKER: "A Therapeutic Aptamer Inhibits Angiogenesis by Specifically Targeting the Heparin Binding Domain of VEGF165", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 102, no. 52, 27 December 2005 (2005-12-27), pages 18902 - 18907, XP008064428, ISSN: 0027-8424, DOI: 10.1073/pnas.0509069102
MORISHITA Y., e al., 39th annual meeting abstract of Japan Society for Biomaterials, 2017.11.13, vol. 39, p. 157 (1P-103-I) whole abstract
ENAM SYED FAAIZ; KRIEGER JACK R.; SAXENA TARUN; WATTS BRIAN E.; OLINGY CLAIRE E.; BOTCHWEY EDWARD A.; BELLAMKONDA RAVI V.: "Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels", BIOMATERIALS, vol. 142, 10 July 2017 (2017-07-10), pages 52 - 61, XP085147120, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2017.07.013
JOON-HAW LEE , MARCELLA D CANNY , ANDREA DE ERKENEZ , DOMINIK KRILLEKE , YIN-SHAN NG , DAVID T SHIMA , ARTHUR PARDI , FIONA JUCKER: "A Therapeutic Aptamer Inhibits Angiogenesis by Specifically Targeting the Heparin Binding Domain of VEGF165", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, vol. 102, no. 52, 27 December 2005 (2005-12-27), pages 18902 - 18907, XP008064428, ISSN: 0027-8424, DOI: 10.1073/pnas.0509069102
Attorney, Agent or Firm:
TSUJIMARU Koichiro et al. (JP)
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