Title:
METHOD FOR PRODUCING PANCREATIC ENDOCRINE CELLS, AND TRANSDIFFERENTIATION AGENT
Document Type and Number:
WIPO Patent Application WO/2017/073740
Kind Code:
A1
Abstract:
A method for producing pancreatic endocrine cells, said method comprising an introduction step in which any of the following genes or gene products are introduced into somatic cells: (A) a mutant GLIS1 gene or gene product thereof having at least 85% sequence identity with the nucleic acid sequence represented by SEQ. ID No. 1 or 2, a Neurogenin-3 gene or gene product thereof, a Pdx1 gene or gene product thereof, and a MafA gene or gene product thereof; (B) a mutant GLIS1 gene or gene product thereof having at least 85% sequence identity with the nucleic acid sequence represented by SEQ. ID No. 1 or 2, a Neurogenin-3 gene or gene product thereof, and a Pdx1 gene or gene product thereof; (C) a GLIS1 gene or gene product thereof, a Neurogenin-3 gene or gene product thereof, a Pdx1 gene or gene product thereof, and a MafA gene or gene product thereof; and (D) a mutant GLIS1 gene or gene product thereof having at least 85% sequence identity with the nucleic acid sequence represented by SEQ. ID No. 1 or 2, a Neurogenin-3 gene or gene product thereof, and a MafA gene or gene product thereof.
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Inventors:
MATSUMOTO MASAHITO (JP)
OKAZAKI YASUSHI (JP)
SUGAHARA IZUMI (JP)
OKAZAKI YASUSHI (JP)
SUGAHARA IZUMI (JP)
Application Number:
PCT/JP2016/082095
Publication Date:
May 04, 2017
Filing Date:
October 28, 2016
Export Citation:
Assignee:
UNIV SAITAMA MEDICAL (JP)
International Classes:
C12N5/10; C07K14/435; C12N5/071; C12N15/09
Domestic Patent References:
| WO2016002937A1 | 2016-01-07 |
Foreign References:
| JP2013519371A | 2013-05-30 |
Other References:
ZHOU, Q. ET AL.: "In vivo reprogramming of adult pancreatic exocrine cells to beta-cells", NATURE, vol. 455, 2008, pages 627 - 632, XP002537767, ISSN: 0028-0836
See also references of EP 3369811A4
See also references of EP 3369811A4
Attorney, Agent or Firm:
HIROTA, Koichi et al. (JP)
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