Title:
METHOD FOR PRODUCING PNA OLIGOMER IN SOLUTION PROCESS
Document Type and Number:
WIPO Patent Application WO/2021/133033
Kind Code:
A1
Abstract:
The present invention provides a method for producing a PNA oligomer. More specifically, the method comprises a step for reacting a PNA block and a PNA block in a solution to produce a PNA oligomer, and thus a PNA oligomer of interest can be produced with remarkably improved purity and yield.
Inventors:
PARK HEE KYUNG (KR)
KIM YONGTAE (KR)
JEON JUHYEON (KR)
JUNG JINWOO (KR)
HONG IN SEOK (KR)
KIM YONGTAE (KR)
JEON JUHYEON (KR)
JUNG JINWOO (KR)
HONG IN SEOK (KR)
Application Number:
PCT/KR2020/018912
Publication Date:
July 01, 2021
Filing Date:
December 22, 2020
Export Citation:
Assignee:
SEASUNBIO MAT (KR)
International Classes:
C07K14/00; C07K1/06
Domestic Patent References:
| WO2005009998A1 | 2005-02-03 |
Foreign References:
| KR20010074672A | 2001-08-08 | |||
| KR20030084444A | 2003-11-01 | |||
| KR20190139890A | 2019-12-18 | |||
| US20080125332A1 | 2008-05-29 |
Other References:
KOVACS G., ET AL: "Synthesis and analysis of peptide nucleic acid oligomers using Fmoc/acyl-protected monomers", JOURNAL OF THE CHEMICAL SOCIETY, PERKIN TRANSACTIONS 1, 23 April 2002 (2002-04-23), Cambridge, UK, pages 1266 - 1270, XP002408946, ISSN: 0300-922X, DOI: 10.1039/b201297a
FARESE, A. PATINO, N. CONDOM, R. DALLEU, S. GUEDJ, R.: "Liquid phase synthesis of a peptidic nucleic acid dimer", TETRAHEDRON LETTERS, vol. 37, no. 9, 26 February 1996 (1996-02-26), Amsterdam , NL, pages 1413 - 1416, XP004705227, ISSN: 0040-4039, DOI: 10.1016/0040-4039(96)00037-8
FILBERT TOTSINGAN, AL. CHIRALITY, vol. 21, 2009, pages 245 - 253
See also references of EP 4083054A4
FARESE, A. PATINO, N. CONDOM, R. DALLEU, S. GUEDJ, R.: "Liquid phase synthesis of a peptidic nucleic acid dimer", TETRAHEDRON LETTERS, vol. 37, no. 9, 26 February 1996 (1996-02-26), Amsterdam , NL, pages 1413 - 1416, XP004705227, ISSN: 0040-4039, DOI: 10.1016/0040-4039(96)00037-8
FILBERT TOTSINGAN, AL. CHIRALITY, vol. 21, 2009, pages 245 - 253
See also references of EP 4083054A4
Attorney, Agent or Firm:
PLUS INTERNATIONAL IP LAW FIRM (KR)
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