Title:
METHOD FOR PRODUCING SUGAR INCLUDING LACTO-N-TRIOSE II AS CORE TRISACCHARIDE AND METHOD FOR PRODUCING CRYSTALS OF SAID SUGAR
Document Type and Number:
WIPO Patent Application WO/2023/120615
Kind Code:
A1
Abstract:
The present invention relates to microorganisms that have enhanced, reduced, or inactivated activity of any of [1] a protein composed of an amino acid sequence represented by SEQ ID NO: 2 or 4, [2] a mutant protein that is composed of an amino acid sequence in which 1-20 amino acids in the amino acid sequence represented by SEQ ID NO: 2 or 4 have been deleted, substituted, inserted, or added and that has oligosaccharide transport activity, and [3] a homologous protein that is composed of an amino acid sequence having 90% or greater identity with the amino acid sequence represented by SEQ ID NO: 2 or 4 and that has oligosaccharide transport activity, the microorganisms also having improved productivity of lacto-N-triose II or an oligosaccharide having a lacto-N-triose II skeleton over that of a parent strain.
Inventors:
SUGITA TOMOTOSHI (JP)
SANPEI SOTARO (JP)
SANPEI SOTARO (JP)
Application Number:
PCT/JP2022/047244
Publication Date:
June 29, 2023
Filing Date:
December 21, 2022
Export Citation:
Assignee:
KYOWA HAKKO BIO CO LTD (JP)
KIRIN HOLDINGS KK (JP)
KIRIN HOLDINGS KK (JP)
International Classes:
C12N1/21; C12N1/15; C12N1/19; C12N15/31; C12P19/00
Domestic Patent References:
| WO2021013708A1 | 2021-01-28 | |||
| WO2002100875A1 | 2002-12-19 | |||
| WO2022157213A1 | 2022-07-28 | |||
| WO2021259670A1 | 2021-12-30 |
Foreign References:
| JP2018526019A | 2018-09-13 |
Attorney, Agent or Firm:
Eikoh, P.C. (JP)
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