Title:
METHOD FOR PRODUCING UMBILICAL CORD-DERIVED MESENCHYMAL CELLS HIGHLY EXPRESSING VASCULAR ENDOTHELIAL GROWTH FACTOR, AND PHARMACEUTICAL COMPOSITION FOR TREATING PULMONARY DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/019080
Kind Code:
A1
Abstract:
The present invention provides: a method for producing umbilical cord-derived mesenchymal cells that highly express a vascular endothelial growth factor, the method comprising a step for culturing an umbilical cord-derived mesenchymal stem cell on a collagen gel; and a pharmaceutical composition that is for treating pulmonary diseases, and that contains, as an active ingredient, the produced umbilical cord-derived mesenchymal cells that highly express a vascular endothelial growth factor.
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Inventors:
TSUCHIYA TOMOSHI (JP)
NAGAYASU TAKESHI (JP)
IWATAKE MAYUMI (JP)
SUMITA YOSHINORI (JP)
NAGAYASU TAKESHI (JP)
IWATAKE MAYUMI (JP)
SUMITA YOSHINORI (JP)
Application Number:
PCT/JP2023/026381
Publication Date:
January 25, 2024
Filing Date:
July 19, 2023
Export Citation:
Assignee:
UNIV NAGASAKI (JP)
International Classes:
C12N5/077; A61K35/51; A61P3/00; A61P3/10; A61P9/00; A61P11/00; A61P19/10; A61P21/00; A61P43/00; C12N5/0775
Domestic Patent References:
| WO2022092307A1 | 2022-05-05 | |||
| WO2021200744A1 | 2021-10-07 | |||
| WO2020217652A1 | 2020-10-29 | |||
| WO2014200068A1 | 2014-12-18 | |||
| WO2014103534A1 | 2014-07-03 | |||
| WO2016010082A1 | 2016-01-21 | |||
| WO2012137970A1 | 2012-10-11 |
Foreign References:
| CN106581760A | 2017-04-26 |
Other References:
ZHANG ZHENKUN; LI ZHE; LI YA; WANG YINGYING; YAO MINGHAO; ZHANG KUN; CHEN ZHENYU; YUE HAN; SHI JIJING; GUAN FANGXIA; MA SHANSHAN: "Sodium alginate/collagen hydrogel loaded with human umbilical cord mesenchymal stem cells promotes wound healing and skin remodeling", CELL AND TISSUE RESEARCH, SPRINGER, DE, vol. 383, no. 2, 1 January 1900 (1900-01-01), DE , pages 809 - 821, XP037379636, ISSN: 0302-766X, DOI: 10.1007/s00441-020-03321-7
NAMBA FUMIHIKO: "Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia", PEDIATRICS INTERNATIONAL, JAPAN PEDIATRIC SOCIETY, HOBOKEN, USA, vol. 61, no. 10, 1 October 2019 (2019-10-01), Hoboken, USA, pages 945 - 950, XP093131741, ISSN: 1328-8067, DOI: 10.1111/ped.14001
NAMBA FUMIHIKO: "Mesenchymal stem cells for the prevention of bronchopulmonary dysplasia", PEDIATRICS INTERNATIONAL, JAPAN PEDIATRIC SOCIETY, HOBOKEN, USA, vol. 61, no. 10, 1 October 2019 (2019-10-01), Hoboken, USA, pages 945 - 950, XP093131741, ISSN: 1328-8067, DOI: 10.1111/ped.14001
Attorney, Agent or Firm:
IWATANI Ryo (JP)
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