Title:
METHOD FOR PROMOTING DIFFERENTIATION OF STEM CELL INTO MATURE CARDIOMYOCYTE THROUGH TOMATIDINE TREATMENT
Document Type and Number:
WIPO Patent Application WO/2020/242045
Kind Code:
A1
Abstract:
The present invention relates to a method for treating a stem cell with tomatidine to promote the differentiation and maturation thereof into a cardiomyocyte. The present invention increases the efficiency of cardiomyocyte differentiation by treating a stem cell with tomatidine during the differentiation thereof into a cardiomyocyte, and exhibits a remarkable effect in that the cardiomyocyte produced through tomatidine treatment is similar in structure and function to a mature human cardiomyocyte. Thus, the present invention is expected to be usefully applied to an evaluation platform for developing a cell therapy agent for treating myocardial infarction, or a medicine for testing for cardiac toxicity or treating heart disease.
Inventors:
KIM JAE HO (KR)
KIM YE SEUL (KR)
YOON JUNG WON (KR)
KIM YE SEUL (KR)
YOON JUNG WON (KR)
Application Number:
PCT/KR2020/004841
Publication Date:
December 03, 2020
Filing Date:
April 09, 2020
Export Citation:
Assignee:
NAT UNIV PUSAN IND UNIV COOP FOUND (KR)
International Classes:
C12N5/077; A61K35/34; A61P9/00
Domestic Patent References:
| WO2015002724A2 | 2015-01-08 |
Foreign References:
| JP2007528705A | 2007-10-18 | |||
| JP2013507135A | 2013-03-04 | |||
| KR20170051497A | 2017-05-11 |
Other References:
SILVA DOS SANTOS, D.: "Embryonic stem cell -derived cardiomyocytes for the treatment of doxorubicin-induced cardiomyopathy", STEM CELL RESEARCH & THERAPY, vol. 9, no. 303, 2018, XP055770107
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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