Title:
METHOD FOR RECYCLING S-ADENOSYLMETHIONINE
Document Type and Number:
WIPO Patent Application WO/2019/160059
Kind Code:
A1
Abstract:
Provided is a method for recycling s-adenosylmethionine that is characterized in that after s-adenosylmethionine is demethylated, s-adenosylmethionine is regenerated by converting s-adenosylmethionine from methionine obtained by transferring a methyl group derived from methanol. Since the present invention enables the regeneration of s-adenosylmethionine (SAM) through the addition of methanol, a wider use of SAM in various methylation reactions can be achieved, thus making the present invention extremely useful in fields pertaining to the production of drugs, chemicals, functional compounds, and the like.
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Inventors:
OKANO KENJI (JP)
HONDA KOHSUKE (JP)
HONDA KOHSUKE (JP)
Application Number:
PCT/JP2019/005427
Publication Date:
August 22, 2019
Filing Date:
February 14, 2019
Export Citation:
Assignee:
UNIV OSAKA (JP)
International Classes:
C12P13/12; C07H19/167; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/53; C12N15/54; C12N15/63; C12P19/40
Domestic Patent References:
| WO2011011627A1 | 2011-01-27 | |||
| WO2014112627A1 | 2014-07-24 | |||
| WO2008020595A1 | 2008-02-21 |
Foreign References:
| JPS5840096A | 1983-03-08 |
Other References:
WHITAKER, W. B. ET AL.: "Engineering the biological conversion of methanol to specialty chemicals in Escherichia coli.", METABOLIC ENGINEERING, vol. 39, 1 November 2016 (2016-11-01), pages 49 - 59, XP029880989, doi:10.1016/j.ymben.2016.10.015
MULLER, J.E.N. ET AL.: "Engineering Escherichia coli for methanol conversion.", METABOLIC ENGINEERING, vol. 28, 14 January 2015 (2015-01-14), pages 190 - 201, XP055255408, doi:10.1016/j.ymben.2014.12.008
WITTHOFF, S. ET AL.: "Metabolic engineering of Corynebacterium glutamicum for methanol metabolism", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 81, no. 6, 16 January 2015 (2015-01-16), pages 2215 - 2225, XP055421495, doi:10.1128/AEM.03110-14
WU, T.-Y. ET AL.: "Characterization and evolution of an activator-independent methanol dehydrogenase from Cupriavidus necator N-1.", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 100, no. 11, 5 February 2016 (2016-02-05), pages 4969 - 4983, XP035750003
MULLER, J.E.N. ET AL.: "Engineering Escherichia coli for methanol conversion.", METABOLIC ENGINEERING, vol. 28, 14 January 2015 (2015-01-14), pages 190 - 201, XP055255408, doi:10.1016/j.ymben.2014.12.008
WITTHOFF, S. ET AL.: "Metabolic engineering of Corynebacterium glutamicum for methanol metabolism", APPLIED AND ENVIRONMENTAL MICROBIOLOGY, vol. 81, no. 6, 16 January 2015 (2015-01-16), pages 2215 - 2225, XP055421495, doi:10.1128/AEM.03110-14
WU, T.-Y. ET AL.: "Characterization and evolution of an activator-independent methanol dehydrogenase from Cupriavidus necator N-1.", APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 100, no. 11, 5 February 2016 (2016-02-05), pages 4969 - 4983, XP035750003
Attorney, Agent or Firm:
IWATANI, Ryo (JP)
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