Title:
METHOD FOR SCREENING ANTISENSE OLIGONUCLEOTIDE DRUG
Document Type and Number:
WIPO Patent Application WO/2021/177419
Kind Code:
A1
Abstract:
The present invention provides: a method for screening a drug for treatment, prevention, and/or amelioration of calmodulinopathy that includes an antisense oligonucleotide; and a drug for treatment, prevention, and/or amelioration of calmodulinopathy that includes an antisense oligonucleotide for inhibiting expression of a calmodulin gene.
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Inventors:
MAKIYAMA TAKERU (JP)
YAMAMOTO YUTA (JP)
IRIYAMA YUSUKE (JP)
KONDO YOSHIKI (JP)
HIDAKA YUUKI (JP)
ISHIKAWA RYUTAROU (JP)
YAMAMOTO YUTA (JP)
IRIYAMA YUSUKE (JP)
KONDO YOSHIKI (JP)
HIDAKA YUUKI (JP)
ISHIKAWA RYUTAROU (JP)
Application Number:
PCT/JP2021/008515
Publication Date:
September 10, 2021
Filing Date:
March 04, 2021
Export Citation:
Assignee:
UNIV KYOTO (JP)
NISSAN CHEMICAL CORP (JP)
NISSAN CHEMICAL CORP (JP)
International Classes:
C12Q1/02; A61K31/7088; A61K48/00; A61P9/06; A61P43/00; C12N5/10; C12N15/113; C12Q1/6851; C12Q1/686; G01N33/15; G01N33/50
Foreign References:
| JPH06500556A | 1994-01-20 |
Other References:
ARRUDA LIGIA H., CESTARI IDÁGENE A., LEIRNER ADOLFO A., CESTARI ISMAR N.: "Adenoviral Expression of Calmodulin Antisense Reduces Hypertrophy in Cultured Cardiomyocytes", ARTIFICIAL ORGANS, vol. 31, no. 4, April 2007 (2007-04-01), pages 274 - 277, XP055852470
LIEBERT MARY ANN, INC, HOU WANG-FANG, ZHANG SUI-PO, DAVIDKOVA GENOVEVA, NICHOLS ROBERT A, WEISS BENJAMIN: "Effect of Antisense Oligodeoxynucleotides Directed to Individual Calmodulin Gene Transcripts on the Proliferation and Differentiation of PC12 Cells", ANTISENSE AND NUCLEIC ACID DRUG DEVELOPMENT, vol. 8, no. 4, 1998, pages 295 - 308, XP055852472
YAMAMOTO YUTA, MAKIYAMA TAKERU, HARITA TAKESHI, SASAKI KENICHI, WURIYANGHAI YIMIN, HAYANO MAMORU, NISHIUCHI SUGURU, KOHJITANI HIRO: "Allele-specific; ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation", HUMAN MOLECULAR GENETICS, vol. 26, no. 9, 1 May 2017 (2017-05-01), pages 1670 - 1677, XP055852474
LIMPITIKUL WORAWAN B., DICK IVY E., TESTER DAVID J., BOCZEK NICOLE J., LIMPHONG PATTRARANEE, YANG WANJUN, CHOI MYOUNG HYUN, BABICH: "A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome", CIRCULATION RESEARCH, vol. 120, no. 1, 6 January 2017 (2017-01-06), pages 39 - 48, XP055852475
YAMAMOTO, YUTA ET AL.: "Calmodulinopathy-Analysis of Human iPS Cell Model of Long-QT Syndrome with a CALM2 Mutation and Therapeutic Approach Using Genome Editing Technology", JAPANESE JOURNAL OF ELECTROCARDIOLOGY, vol. 39, no. 4, 2019, pages 273 - 282
LIEBERT MARY ANN, INC, HOU WANG-FANG, ZHANG SUI-PO, DAVIDKOVA GENOVEVA, NICHOLS ROBERT A, WEISS BENJAMIN: "Effect of Antisense Oligodeoxynucleotides Directed to Individual Calmodulin Gene Transcripts on the Proliferation and Differentiation of PC12 Cells", ANTISENSE AND NUCLEIC ACID DRUG DEVELOPMENT, vol. 8, no. 4, 1998, pages 295 - 308, XP055852472
YAMAMOTO YUTA, MAKIYAMA TAKERU, HARITA TAKESHI, SASAKI KENICHI, WURIYANGHAI YIMIN, HAYANO MAMORU, NISHIUCHI SUGURU, KOHJITANI HIRO: "Allele-specific; ablation rescues electrophysiological abnormalities in a human iPS cell model of long-QT syndrome with a CALM2 mutation", HUMAN MOLECULAR GENETICS, vol. 26, no. 9, 1 May 2017 (2017-05-01), pages 1670 - 1677, XP055852474
LIMPITIKUL WORAWAN B., DICK IVY E., TESTER DAVID J., BOCZEK NICOLE J., LIMPHONG PATTRARANEE, YANG WANJUN, CHOI MYOUNG HYUN, BABICH: "A Precision Medicine Approach to the Rescue of Function on Malignant Calmodulinopathic Long-QT Syndrome", CIRCULATION RESEARCH, vol. 120, no. 1, 6 January 2017 (2017-01-06), pages 39 - 48, XP055852475
YAMAMOTO, YUTA ET AL.: "Calmodulinopathy-Analysis of Human iPS Cell Model of Long-QT Syndrome with a CALM2 Mutation and Therapeutic Approach Using Genome Editing Technology", JAPANESE JOURNAL OF ELECTROCARDIOLOGY, vol. 39, no. 4, 2019, pages 273 - 282
Attorney, Agent or Firm:
TSUKUNI & ASSOCIATES et al. (JP)
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