Title:
METHOD FOR SEMISYNTHESIS OF NMN INVOLVING ADENOSINE
Document Type and Number:
WIPO Patent Application WO/2023/273960
Kind Code:
A1
Abstract:
Provided is a method for semisynthesis of NMN involving adenosine. The method for semisynthesis of NMN involving adenosine comprises the steps in the same reaction system: (A) a step of adenosine, a phosphate and a sugar that can be metabolized by yeast cells reacting, catalyzed by yeast cells, to generate ATP; (B) a step of enzymatic phosphorylation of NR, and a corresponding step of NR reacting with ATP under the catalysis of NRK to generate NMN and ADP. In this way, efficient synthesis of NMN can be realized during a process of ATP generation and recycling, which can simplify the process and reduce emissions.
More Like This:
Inventors:
JIN CAIKE (CN)
ZHAO YUAN (CN)
ZHAO YUAN (CN)
Application Number:
PCT/CN2022/100140
Publication Date:
January 05, 2023
Filing Date:
June 21, 2022
Export Citation:
Assignee:
RUBYBERRIES BIOTECHNOLOGIES CO LTD (CN)
International Classes:
C12P19/30; C12P19/32; C12R1/84; C12R1/865
Domestic Patent References:
| WO2018120069A1 | 2018-07-05 |
Foreign References:
| CN113481262A | 2021-10-08 | |||
| CN110373398A | 2019-10-25 | |||
| CN104762347A | 2015-07-08 |
Other References:
LI YIN, CHEN JIAN, LUN SHIYI: "ATP Regeneration System and It's Application", FOOD AND FERMENTATION INDUSTRIES, vol. 24, no. 3, 31 December 1998 (1998-12-31), XP093018896, DOI: 10.13995/j.cnki.11-1802/ts.1998.03.014
SHI HAIBO, ZHAO HAI; ZHOU CHUNSONG; WANG QUANMING: "Progress in Synthsis of β-Nicotinamide Mononucleotide", JINGXI HUAGONG ZHONGJIANTI = FINE CHEMICAL INTERMEDIATES, JINGXI HUAGONG ZHONGJIANTI,, CH, vol. 50, no. 4, 31 August 2020 (2020-08-31), CH , pages 1 - 5, XP093018891, ISSN: 1009-9212, DOI: 10.19342/j.cnki.issn.1009-9212.2020.04.001
FLETCHER RACHEL S., RATAJCZAK JOANNA, DOIG CRAIG L., OAKEY LUCY A., CALLINGHAM REBECCA, DA SILVA XAVIER GABRIELLA, GARTEN ANTJE, E: "Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells", MOLECULAR METABOLISM, vol. 6, no. 8, 1 August 2017 (2017-08-01), pages 819 - 832, XP093018884, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.05.011
SHI HAIBO, ZHAO HAI; ZHOU CHUNSONG; WANG QUANMING: "Progress in Synthsis of β-Nicotinamide Mononucleotide", JINGXI HUAGONG ZHONGJIANTI = FINE CHEMICAL INTERMEDIATES, JINGXI HUAGONG ZHONGJIANTI,, CH, vol. 50, no. 4, 31 August 2020 (2020-08-31), CH , pages 1 - 5, XP093018891, ISSN: 1009-9212, DOI: 10.19342/j.cnki.issn.1009-9212.2020.04.001
FLETCHER RACHEL S., RATAJCZAK JOANNA, DOIG CRAIG L., OAKEY LUCY A., CALLINGHAM REBECCA, DA SILVA XAVIER GABRIELLA, GARTEN ANTJE, E: "Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells", MOLECULAR METABOLISM, vol. 6, no. 8, 1 August 2017 (2017-08-01), pages 819 - 832, XP093018884, ISSN: 2212-8778, DOI: 10.1016/j.molmet.2017.05.011
Attorney, Agent or Firm:
GUANGDONG FAREN LAW FIRM (CN)
Download PDF:
Previous Patent: ADENOSINE-INVOLVED FULLY ENZYMATIC SYNTHESIS METHOD FOR NMN
Next Patent: SUPPORT SHEET, FLEXIBLE DISPLAY SCREEN AND ELECTRONIC DEVICE
Next Patent: SUPPORT SHEET, FLEXIBLE DISPLAY SCREEN AND ELECTRONIC DEVICE