Title:
ADENOSINE-INVOLVED FULLY ENZYMATIC SYNTHESIS METHOD FOR NMN
Document Type and Number:
WIPO Patent Application WO/2023/273959
Kind Code:
A1
Abstract:
Provided is an adenosine-involved fully enzymatic synthesis method for NMN. The adenosine-involved fully enzymatic synthesis method for NMN comprises the steps under the same reaction system: (A) reacting, under the catalytic action of a yeast cell, adenosine, phosphate and sugar that is metabolizable by a yeast cell, so as to generate ATP; and (B) the step of generating NMN by an enzymatic reaction, comprising the step of under the action of NAMPT, reacting nicotinamide, PRPP and ATP to generate NMN, ADP and phosphate. In this way, a series of reactions such as the generation (regeneration) of ATP, the synthesis of NMN and the utilization of ATP are performed in one reaction system in a unified manner, and thus efficient synthesis of NMN can be implemented.
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Inventors:
JIN CAIKE (CN)
ZHAO YUAN (CN)
ZHAO YUAN (CN)
Application Number:
PCT/CN2022/100139
Publication Date:
January 05, 2023
Filing Date:
June 21, 2022
Export Citation:
Assignee:
RUBYBERRIES BIOTECHNOLOGIES CO LTD (CN)
International Classes:
C12P19/30; C12P19/32; C12R1/84; C12R1/865
Foreign References:
| CN111051520A | 2020-04-21 | |||
| CN104762347A | 2015-07-08 | |||
| CN111187759A | 2020-05-22 | |||
| US20210108242A1 | 2021-04-15 | |||
| CN112877386A | 2021-06-01 | |||
| CN112961890A | 2021-06-15 |
Other References:
LI YIN, CHEN JIAN, LUN SHIYI: "ATP Regeneration System and Its Application", FOOD AND FERMENTATION INDUSTRIES, vol. 24, no. 3, 31 December 1998 (1998-12-31), XP093018944, DOI: 10.13995/j.cnki.11-1803/ts.1998.03.014
Attorney, Agent or Firm:
GUANGDONG FAREN LAW FIRM (CN)
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