Title:
METHOD FOR SITE-DIRECTED SYNTHESIS OF PROTEIN-ACTIVE MOLECULAR CONJUGATE
Document Type and Number:
WIPO Patent Application WO/2024/022313
Kind Code:
A1
Abstract:
Provided is a bioconjugation technique, specifically provided is a protein covalent modification technique, i.e., provided is a protein moiety-linker conjugate, which can be used as an intermediate for synthesizing a protein-active molecular conjugate. Further provided are a method for preparing the protein moiety-linker conjugate, and a method for synthesizing a protein-active molecular conjugate by means of using the protein moiety-linker conjugate as an intermediate. The method has a higher conversion rate and fewer by-products.
Inventors:
GUO CHUN (CN)
XU KANG (CN)
CHEN CHEN (CN)
WANG JIANPENG (CN)
LI HONG (CN)
XU KANG (CN)
CHEN CHEN (CN)
WANG JIANPENG (CN)
LI HONG (CN)
Application Number:
PCT/CN2023/109032
Publication Date:
February 01, 2024
Filing Date:
July 25, 2023
Export Citation:
Assignee:
NANJING GENSCRIPT BIOTECH CO LTD (CN)
International Classes:
C07K1/107; C07D401/14; C07K1/10
Domestic Patent References:
| WO2022078566A1 | 2022-04-21 | |||
| WO2022115625A1 | 2022-06-02 |
Foreign References:
| CN113512093A | 2021-10-19 | |||
| US20200199175A1 | 2020-06-25 | |||
| CN109305936A | 2019-02-05 | |||
| US20080300348A1 | 2008-12-04 | |||
| US20200030453A1 | 2020-01-30 |
Other References:
SANTOSHKUMAR L. KHATWANI; JUN SUNG KANG; DANIEL G. MULLEN; MICHAEL A. HAST; LORENA S. BEESE; MARK D. DISTEFANO; T. ANDREW TATON;: "Covalent proteinoligonucleotide conjugates by copper-free click reaction", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER, AMSTERDAM, NL, vol. 20, no. 14, 9 May 2012 (2012-05-09), AMSTERDAM, NL, pages 4532 - 4539, XP028502318, ISSN: 0968-0896, DOI: 10.1016/j.bmc.2012.05.017
Attorney, Agent or Firm:
CHENG & PENG INTELLECTUAL PROPERTY LAW OFFICE (CN)
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