Title:
METHOD OF TREATING COGNITIVE DYSFUNCTION SYNDROME IN DOGS AND CHEWABLE TABLET FOR DOGS
Document Type and Number:
WIPO Patent Application WO2001021178
Kind Code:
A3
Abstract:
Methods of treating cognitive dysfunction syndrome in dogs. The method includes identifying dogs that have cognitive dysfunction syndrome and administering to them propentofylline. The amount of propentofylline administered to the dogs is an effective amount to treat cognitive dysfunction syndrome. Also described are chewable tablets for dogs containing propentofylline and at least one flavor enhancing ingredient. The tablet may also contain binders, lubricants and/or antioxidants.
Inventors:
ABBOTT ELIZABETH M (US)
CADY SUSAN M (US)
CADY SUSAN M (US)
Application Number:
PCT/US2000/025771
Publication Date:
July 11, 2002
Filing Date:
September 21, 2000
Export Citation:
Assignee:
AKZO NOBEL NV (NL)
ABBOTT ELIZABETH M (US)
CADY SUSAN M (US)
ABBOTT ELIZABETH M (US)
CADY SUSAN M (US)
International Classes:
A61K9/00; A61K31/522; A61P25/22; A61P25/28; (IPC1-7): A61K31/522; A61D7/00; A61K9/20; A61K9/44; A61P25/22; A61P25/28
Foreign References:
| EP0748628A2 | 1996-12-18 | |||
| US5780046A | 1998-07-14 | |||
| US5824336A | 1998-10-20 | |||
| US4937076A | 1990-06-26 |
Other References:
KAPL ET AL.: "Neue pharmakologische Aspekte zum neurologischen Profil von Propentofyllin (Karsivan(R) ad us. evt.)", TIERARZTLICHE PRAXIS, AUSGABE K., KLEINTIERE/HEIMTIERE, vol. 26, no. 5, September 1998 (1998-09-01), pages 317 - 321, XP001035000
NOBLE S ET AL: "PROPENTOFYLLINE", CNS DRUGS, ADIS INTERNATIONAL, AUCKLAND, NZ, vol. 8, no. 3, 1997, pages 257 - 264, XP000863567, ISSN: 1172-7047
FUJI ET AL.: "Effects of repeated adminisitration of propentofylline on memory impairment produced by basal forebrain lesion in rats", EUR. J. PHARMACOL., vol. 236, no. 3, 4 June 1993 (1993-06-04), pages 411 - 417, XP001034927
STEVENS ET AL.: "Pharmacokinetic studies on HWA 285 in the dog following single oral and intravenous administrations and multiple oral dose administration", JAPANESE PHARMACOL. THER., vol. 144, 1986, pages 25 - 36, XP001034959
GOTO ET AL.: "Effects of propentofylline on disorder of learning and memory in rodents", JPN J. PHARMACOL., vol. 45, no. 3, 1987, pages 373 - 378, XP002186238
HUDLICKA ET AL.: "The effect of a xanthine derivative, 1-(5'-oxohexyl)-3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits", BRITISH J. PHARMACOL., vol. 72, no. 4, April 1981 (1981-04-01), pages 723 - 730, XP002186247
SIWAK ET AL.: "Adrafinil: effects on behavior and cognition in aged canines", PROG. NEURO-PSYCHPHARMACOL. BIOL. PSYCHIATRY, vol. 24, no. 5, 27 July 2000 (2000-07-27), pages 709 - 726, XP001051903
NOBLE S ET AL: "PROPENTOFYLLINE", CNS DRUGS, ADIS INTERNATIONAL, AUCKLAND, NZ, vol. 8, no. 3, 1997, pages 257 - 264, XP000863567, ISSN: 1172-7047
FUJI ET AL.: "Effects of repeated adminisitration of propentofylline on memory impairment produced by basal forebrain lesion in rats", EUR. J. PHARMACOL., vol. 236, no. 3, 4 June 1993 (1993-06-04), pages 411 - 417, XP001034927
STEVENS ET AL.: "Pharmacokinetic studies on HWA 285 in the dog following single oral and intravenous administrations and multiple oral dose administration", JAPANESE PHARMACOL. THER., vol. 144, 1986, pages 25 - 36, XP001034959
GOTO ET AL.: "Effects of propentofylline on disorder of learning and memory in rodents", JPN J. PHARMACOL., vol. 45, no. 3, 1987, pages 373 - 378, XP002186238
HUDLICKA ET AL.: "The effect of a xanthine derivative, 1-(5'-oxohexyl)-3-methyl-7-propylxanthine (HWA 285), on heart performance and regional blood flow in dogs and rabbits", BRITISH J. PHARMACOL., vol. 72, no. 4, April 1981 (1981-04-01), pages 723 - 730, XP002186247
SIWAK ET AL.: "Adrafinil: effects on behavior and cognition in aged canines", PROG. NEURO-PSYCHPHARMACOL. BIOL. PSYCHIATRY, vol. 24, no. 5, 27 July 2000 (2000-07-27), pages 709 - 726, XP001051903
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