Title:
PPAR$g(a) AND PPAR$g(g) INHIBITORS
Document Type and Number:
WIPO Patent Application WO/2001/021181
Kind Code:
A1
Abstract:
Highly novel drugs efficacious against diseases in association with glycometabolism and lipid metabolism have been created by finding inhibitors or antagonists to PPAR$g(a) and PPAR$g(g). Use of fatty acid coA thioesters, which have been found out as peroxisome proliferator-activated receptors (PPARs) $g(a) and $g(g) inhibitors, in evaluating drugs and utilization thereof in drugs.
Inventors:
MURAKAMI KOJI (JP)
IDE TOMOHIRO (JP)
MOCHIZUKI TOSHIRO (JP)
KADOWAKI TAKASHI (JP)
IDE TOMOHIRO (JP)
MOCHIZUKI TOSHIRO (JP)
KADOWAKI TAKASHI (JP)
Application Number:
PCT/JP1999/005217
Publication Date:
March 29, 2001
Filing Date:
September 24, 1999
Export Citation:
Assignee:
KYORIN PHARMACEUTICALS CO LTD (JP)
MURAKAMI KOJI (JP)
IDE TOMOHIRO (JP)
MOCHIZUKI TOSHIRO (JP)
KADOWAKI TAKASHI (JP)
MURAKAMI KOJI (JP)
IDE TOMOHIRO (JP)
MOCHIZUKI TOSHIRO (JP)
KADOWAKI TAKASHI (JP)
International Classes:
A61K31/675; (IPC1-7): A61K31/675
Domestic Patent References:
| WO1997010813A1 | 1997-03-27 |
Other References:
OBERFIELD J. L. ET AL.: "A Peroxisome Proliferator-activated Receptor gamma Ligand Inhibits Adipocyte Differentiation", PROC. NATL. ACAD. SCI. USA, vol. 96, May 1999 (1999-05-01), pages 6102 - 6106, XP002925776
Attorney, Agent or Firm:
Minoura, Kiyoshi (7th floor 2-2, Kudankita 3-chome Chiyoda-ku Tokyo, JP)
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