METHOD FOR TREATING LIVER CANCER USING HEPATIC ARTERY ADMINISTRATION OF ONCOLYTIC VIRUS

WIPO Patent Application WO/2019/103449

A3

The present invention relates to a method for treating liver cancer using hepatic artery administration of an oncolytic virus. The method for treating liver cancer using hepatic artery administration of an oncolytic virus according to the present invention optimizes hepatic artery administration conditions and thus is safe, and can maximize an anticancer effect by delivering a larger amount of an oncolytic virus to a tumor while minimizing the exposure of the oncolytic virus. Therefore, the method can be effectively used to treat liver cancer.

WO/2013/072044	CO-ADMINISTRATION OF A PARVOVIRUS AND A CYTOKINE FOR THERAPY OF PANCREATIC CANCER
WO/2011/131703	GENETICALLY MODIFIED SENDAI VIRUS FOR TREATMENT OF TUMOURS
WO/2017/037523	COMPOSITIONS AND METHODS FOR VIRAL EMBOLIZATION

CHO MONG (KR)
JEON UNGBAE (KR)

PCT/KR2018/014337

July 18, 2019

November 21, 2018

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BIONOXX INC (KR)

A61K35/768; A61K9/00; A61K31/43; A61K31/7036; A61K45/06

WO2017037523A1

2017-03-09

KR20080084528A

2008-09-19

CHO, E.: "Safety evaluation of hepatic arterial injection of JX-594 oncolytic vaccinia virus in rat model with progressive liver disease", 2012, pages 1 - 29
CHANG, J.-F.: "Oncolytic virotherapy for advanced liver tumours", J. CELL . MOL. MED., 2009, pages 1238 - 1247, XP055367656
CHO, E.: "Preclinical safety evaluation of hepatic arterial infusion of oncolytic poxvirus", DRUG DES DEVEL THER., no. 12, 8 August 2018 (2018-08-08), pages 2467 - 2474, XP055625010

FIRSTLAW P.C. (KR)

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