Title:
METHOD OF TREATING OCULAR INFLAMMATORY AND ANGIOGENESIS-RELATED DISORDERS USING AN AMIDE DERIVATIVE OF FLUBIPROFEN OR KETOROLAC
Document Type and Number:
WIPO Patent Application WO2002078681
Kind Code:
A3
Abstract:
The topical use of certain flurbiprofen amide derivatives and ketorolac amide derivatives to treat ophthalmic angiogenesis-related and inflammatory disorders of the posterior segment of the eye is disclosed.
Inventors:
GRAFF GUSTAV (US)
HELLBERG MARK R (US)
YANNI JOHN M (US)
HELLBERG MARK R (US)
YANNI JOHN M (US)
Application Number:
PCT/US2002/006958
Publication Date:
May 01, 2003
Filing Date:
March 07, 2002
Export Citation:
Assignee:
ALCON INC (CH)
GRAFF GUSTAV (US)
HELLBERG MARK R (US)
YANNI JOHN M (US)
GRAFF GUSTAV (US)
HELLBERG MARK R (US)
YANNI JOHN M (US)
International Classes:
A61K31/165; A61K31/407; A61P27/02; (IPC1-7): A61K31/165; A61K31/407; A61P27/02
Foreign References:
| US4230724A | 1980-10-28 | |||
| EP0592348A1 | 1994-04-13 | |||
| US4454151A | 1984-06-12 | |||
| US5475034A | 1995-12-12 | |||
| US4988728A | 1991-01-29 |
Other References:
GRAFF G ET AL: "Characterization of in vitro corneal penetration, bioactivation and topical ocular antiinflammatory activity of nepafenac and amide analogs of classical NSAIDs.", IOVS, vol. 42, no. 4, 15 March 2001 (2001-03-15), Annual Meeting of the Association for Research in Vision and Ophthalmology;Fort Lauderdale, Florida, USA; April 29-May 04, 2001, pages S176, XP008011793
SOLOMON L D: "Efficacy of topical flurbiprofen and indomethacin in preventing pseudophakic cystoid macular edema. Flurbiprofen-CME Study Group I.", JOURNAL OF CATARACT AND REFRACTIVE SURGERY. UNITED STATES JAN 1995, vol. 21, no. 1, January 1995 (1995-01-01), pages 73 - 81, XP008011168, ISSN: 0886-3350
KE TAI-LEE ET AL: "Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers.", INFLAMMATION, vol. 24, no. 4, August 2000 (2000-08-01), pages 371 - 384, XP001131917, ISSN: 0360-3997
GAMACHE DANIEL A ET AL: "Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy.", INFLAMMATION, vol. 24, no. 4, August 2000 (2000-08-01), pages 357 - 370, XP001131916, ISSN: 0360-3997
SOLOMON L D: "Efficacy of topical flurbiprofen and indomethacin in preventing pseudophakic cystoid macular edema. Flurbiprofen-CME Study Group I.", JOURNAL OF CATARACT AND REFRACTIVE SURGERY. UNITED STATES JAN 1995, vol. 21, no. 1, January 1995 (1995-01-01), pages 73 - 81, XP008011168, ISSN: 0886-3350
KE TAI-LEE ET AL: "Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers.", INFLAMMATION, vol. 24, no. 4, August 2000 (2000-08-01), pages 371 - 384, XP001131917, ISSN: 0360-3997
GAMACHE DANIEL A ET AL: "Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy.", INFLAMMATION, vol. 24, no. 4, August 2000 (2000-08-01), pages 357 - 370, XP001131916, ISSN: 0360-3997
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