A METHOD FOR THE TREATMENT OF CANCER VIA TUMOR CELL LYSIS AND INTRATUMORAL ADMINISTRATION OF COMBINATIONS OF IMMUNOTHERAPEUTIC INGREDIENTS

WIPO Patent Application WO/2023/235504

A3

The present disclosure provides, among other things, methods of cancer treatment comprising steps of: a) intratumoral cell lysis, mediated by cryolysis; and b) intratumoral administration of 1) a combination of immunotherapeutic agents comprising: i) a TLR9 agonist CpG oligodeoxydinucleotide, ii) an agonistic anti-CD40 monoclonal antibody, iii) an agonistic anti-OX40 monoclonal antibody and iv) an anti-CTLA4 monoclonal antibody; or 2) a combination of immunotherapeutic agents comprising: i) a TLR9 agonist CpG oligodeoxydinucleotide, ii) an agonistic anti-CD40 monoclonal antibody, iii) an anti-PD1 monoclonal antibody and iv) an anti-CTLA4 monoclonal antibody.

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LINK JR (US)
WILLIAMS JASON R (US)
MAUTINO MARIO R (US)
RECINELLA DANIEL K (US)
HOBBS EAMONN P (US)

PCT/US2023/024174

March 14, 2024

June 01, 2023

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SYNCROMUNE INC (US)

C07K16/28; A61K39/395; A61P35/00; C07K16/30; C07K16/46; C07K19/00; C12N15/13

US20170273926A1	2017-09-28
US20200002704A1	2020-01-02
US20210155705A1	2021-05-27
US20200332018A1	2020-10-22
US20200291117A1	2020-09-17
US20200377597A1	2020-12-03
US20200255531A1	2020-08-13

MOLOCHKOV V A: "BASAL CELL AND SQUAMOUS CELL SKIN CANCER. BASAL CELL SKIN CANCER, PHOTOS, TREATMENT AND PROGNOSIS", 2 May 2019 (2019-05-02), pages 1 - 37, XP093149539, Retrieved from the Internet [retrieved on 20240409]

MCCARTY, Catherine M. (US)

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