METHODS AND COMPOSITIONS IN TREATING PAIN AND PAINFUL DISORDERS USING 1465,1587, 2146, 2207, 32838, 336 AND 52908

WIPO Patent Application WO2003053364

A3

The present invention relates to methods for the diagnosis and treatment of pain or painful disorders. Specifically, the present invention identifies the differential expression of 1465, 1587, 2146, 2207, 32838, 336 OR 52908 genes in tissues relating to pain sensation, relative to their expression in normal, or non-painful disease states, and/or in response to manipulations relevant to pain. The present invention describes methods for the diagnostic evaluation and prognosis of various cardiovascular diseases, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating pain or painful disorders. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of pain and painful disorders.

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SILOS-SANTIAGO INMACULADA (US)
ROSENFELD JULIE BETH (US)

PCT/US2002/041011

August 19, 2004

December 19, 2002

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MILLENNIUM PHARM INC (US)
SILOS-SANTIAGO INMACULADA (US)
ROSENFELD JULIE BETH (US)

G01N33/50; A61K31/7088; A61K38/00; A61K39/395; A61K45/00; A61K48/00; A61P1/02; A61P1/12; A61P7/00; A61P9/10; A61P19/00; A61P21/00; A61P25/02; A61P25/04; A61P25/06; A61P29/00; A61P29/02; A61P31/00; A61P35/00; A61P43/00; C07K14/705; C12N15/09; C12Q1/02; C12Q1/34; C12Q1/48; C12Q1/68; G01N33/15; (IPC1-7): G01N33/53; G01N33/567

SALLESE ET AL.: "G protein coupled receptor kinase GRK4. Molecular analysis of the four isoforms and untrastructural localization in spermatozoa and germinal cells", J. BIOL. CHEM., vol. 272, no. 15, 11 April 1997 (1997-04-11), pages 10188 - 10195, XP002955884
MEYERSON ET AL.: "A familly of human cdc2-related protein kinases", EMBO J., vol. 11, no. 8, 1992, pages 2909 - 2917, XP002128265
See also references of EP 1472540A4

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