Title:
METHODS OF IDENTIFYING T-CELL MODULATING GENES
Document Type and Number:
WIPO Patent Application WO/2022/143783
Kind Code:
A1
Abstract:
Provided are methods of identifying genes that modulate the sensitivity or resistance of T cells (e.g., allogeneic T cells or CAR-T cells (such as allogeneic CAR-T cells) ) to NK cell killing. Also provided are modified T cells (e.g., allogeneic T cells or CAR-T cells (such as allogeneic CAR-T cells)) that are resistant to NK cell killing, and methods and kits for generating thereof.
Inventors:
YUAN PENGFEI (CN)
JIN MING (CN)
ZHANG YONGJIAN (CN)
YANG XIAOMEI (CN)
YANG LING (CN)
SU MEIHUA (CN)
ZONG HUIMING (CN)
JIN MING (CN)
ZHANG YONGJIAN (CN)
YANG XIAOMEI (CN)
YANG LING (CN)
SU MEIHUA (CN)
ZONG HUIMING (CN)
Application Number:
PCT/CN2021/142538
Publication Date:
July 07, 2022
Filing Date:
December 29, 2021
Export Citation:
Assignee:
EDIGENE THERAPEUTICS BEIJING INC (CN)
International Classes:
C12N5/0783; A61K35/18; C12N15/113
Domestic Patent References:
| WO2020125762A1 | 2020-06-25 | |||
| WO2020028533A1 | 2020-02-06 | |||
| WO2018195073A2 | 2018-10-25 |
Foreign References:
| CN111349654A | 2020-06-30 | |||
| CN111511903A | 2020-08-07 | |||
| CN110869493A | 2020-03-06 | |||
| CN110616186A | 2019-12-27 |
Other References:
JIANGTAO REN, LIU XIAOJUN, FANG CHONGYUN, JIANG SHUGUANG, JUNE CARL H., ZHAO YANGBING: "Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition", CLINICAL CANCER RESEARCH, ASSOCIATION FOR CANCER RESEARCH, US, vol. 23, no. 9, 1 May 2017 (2017-05-01), US, pages 2255 - 2266, XP055488912, ISSN: 1078-0432, DOI: 10.1158/1078-0432.CCR-16-1300
XIAOJUN LIU, YANGBING ZHAO: "CRISPR/Cas9 genome editing: Fueling the revolution in cancer immunotherapy", CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, vol. 66, no. 2, 1 May 2018 (2018-05-01), pages 39 - 42, XP055641010, ISSN: 2452-3186, DOI: 10.1016/j.retram.2018.04.003
XIAOJUN LIU, YANGBING ZHAO: "CRISPR/Cas9 genome editing: Fueling the revolution in cancer immunotherapy", CURRENT RESEARCH IN TRANSLATIONAL MEDICINE, vol. 66, no. 2, 1 May 2018 (2018-05-01), pages 39 - 42, XP055641010, ISSN: 2452-3186, DOI: 10.1016/j.retram.2018.04.003
Attorney, Agent or Firm:
BEIJING CAIHE LAW FIRM (CN)
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