Title:
METHODS AND KITS FOR SCREENING COLORECTAL NEOPLASM
Document Type and Number:
WIPO Patent Application WO/2021/185061
Kind Code:
A1
Abstract:
Provided are a method of diagnosing colorectal neoplasm, screening for the onset or risk to the onset of colorectal neoplasm or assessing the development or prognosis of colorectal neoplasm in a subject, a method of monitoring treatment response in a subject who is receiving treatment of colorectal neoplasm, and a kit for using in the methods.
Inventors:
LIU RUI (CN)
WANG HUI (CN)
WANG HUI (CN)
Application Number:
PCT/CN2021/078445
Publication Date:
September 23, 2021
Filing Date:
March 01, 2021
Export Citation:
Assignee:
SINGLERA HEALTH TECH SHANGHAI LTD (CN)
International Classes:
C12Q1/68
Domestic Patent References:
| WO2019144277A1 | 2019-08-01 | |||
| WO2015187823A2 | 2015-12-10 | |||
| WO2018140781A1 | 2018-08-02 | |||
| WO2019199696A1 | 2019-10-17 | |||
| WO2015153284A1 | 2015-10-08 |
Foreign References:
| US7888006B2 | 2011-02-15 | |||
| EP1626085A1 | 2006-02-15 | |||
| US6265171B1 | 2001-07-24 |
Other References:
LI JINGYI, ZHOU XIN, LIU XIAOMENG, REN JIE, WANG JILIAN, WANG WENDONG, ZHENG YUXUAN, SHI XINYUN, SUN TAO, LI ZHIFEI, KANG ANDING, : "Detection of Colorectal Cancer in Circulating Cell-Free DNA by Methylated CpG Tandem Amplification and Sequencing", CLINICAL CHEMISTRY, OXFORD UNIVERSITY PRESS, US, vol. 65, no. 7, 1 July 2019 (2019-07-01), US, pages 916 - 926, XP055821424, ISSN: 0009-9147, DOI: 10.1373/clinchem.2019.301804
HINOUE T., WEISENBERGER D. J., LANGE C. P. E., SHEN H., BYUN H.-M., VAN DEN BERG D., MALIK S., PAN F., NOUSHMEHR H., VAN DIJK C. M: "Genome-scale analysis of aberrant DNA methylation in colorectal cancer", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 22, no. 2, 1 February 2012 (2012-02-01), US, pages 271 - 282, XP055821428, ISSN: 1088-9051, DOI: 10.1101/gr.117523.110
DOWDYWEARDEN: "Statistics for Research", 1983, JOHN WILEY & SONS
SAMBROOK, J.FRITSCH, E. F.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR PRESS
FROMMER, M. ET AL., PROC NATL ACAD SCI USA, vol. 89, 1992, pages 1827 - 31
GRIGG, G.CLARK, S., BIOESSAYS, vol. 16, 1994, pages 431 - 6
ALTSCHUL S.F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
STEPHEN F. ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
HIGGINS D.G. ET AL., METHODS IN ENZYMOLOGY, vol. 266, 1996, pages 383 - 402
LARKIN M.A. ET AL., BIOINFORMATICS (OXFORD, ENGLAND, vol. 23, no. 21, 2007, pages 2947 - 8
"PCR Primer: A Laboratory Manual", 1995, COLD SPRING HARBOR LABORATORIES
LI LCDAHIYA R: "MethPrimer: designing primers for methylation PCRs", BIOINFORMATICS, vol. 18, no. 11, November 2002 (2002-11-01), pages 1427 - 31
M. KANEHISA, NUCLEIC ACIDS RES., vol. 12, 1984, pages 203
HERMAN ET AL.: "Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands", PROC NATL ACAD SCI USA., vol. 93, no. 18, 3 September 1996 (1996-09-03), pages 9821 - 6, XP002542477, DOI: 10.1073/pnas.93.18.9821
ANDERSONYOUNG: "Quantitative Filter Hybridization", NUCLEIC ACID HYBRIDIZATION, 1985
ALLAWISANTALUCIA, JR., BIOCHEMISTRY, vol. 36, 1997, pages 10581 - 94
EADS ET AL., CANCER RES., vol. 59, 1999, pages 2302 - 2306
YU ET AL., BIOTECHNIQUES, vol. 23, 1997, pages 714 - 720
COTTRELL ET AL., NUCL. ACIDS RES., vol. 32, 2003, pages e10
RAND ET AL., NUCL. ACIDS RES., vol. 33, 2005, pages e 127
HOLLAND ET AL., PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 7276 - 7280
MHLANGAMALMBERG, METHODS, vol. 25, 2001, pages 463 - 471
FROMMER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 1827 - 1831
CLARK ET AL., NUCL. ACIDS RES., vol. 22, 1994, pages 2990 - 2997
UHLMANN ET AL., ELECTROPHORESIS, vol. 23, 2002, pages 4072 - 4079
LANDEGREN ET AL., GENOME RES., vol. 8, no. 8, 1998, pages 769 - 776
SOUTHERN ET AL., GENOMICS, vol. 13, 1992, pages 1008 - 1017
MARGUILES ET AL., NATURE, vol. 437, no. 7057, 2005, pages 376 - 80
XIONGLAIRD, NUCL. ACIDS RES., vol. 25, 2001, pages 2532 - 2534
BIANCO ET AL., HUM. MUTAT., vol. 14, 1999, pages 289 - 293
ABRAMSSTANTON, METHODS ENZYMOL., vol. 212, 1992, pages 71 - 74
DENG ET AL., CHIN. J. CANCER RES., vol. 12, 2000, pages 171 - 191
KAWAI ET AL., MOL. CELL. BIOL., vol. 14, 1994, pages 7421 - 7427
GONZALGO ET AL., CANCER RES., vol. 57, pages 594 - 599
ADORJAN ET AL., NUCL. ACIDS RES., vol. 30, 2002, pages e21
FREDERICK M.AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1998, SCIENCE PRESS
T.R. CHURCH ET AL., GUT., vol. 63, 2014, pages 317 - 325
See also references of EP 3911756A4
HINOUE T., WEISENBERGER D. J., LANGE C. P. E., SHEN H., BYUN H.-M., VAN DEN BERG D., MALIK S., PAN F., NOUSHMEHR H., VAN DIJK C. M: "Genome-scale analysis of aberrant DNA methylation in colorectal cancer", GENOME RESEARCH, COLD SPRING HARBOR LABORATORY PRESS, US, vol. 22, no. 2, 1 February 2012 (2012-02-01), US, pages 271 - 282, XP055821428, ISSN: 1088-9051, DOI: 10.1101/gr.117523.110
DOWDYWEARDEN: "Statistics for Research", 1983, JOHN WILEY & SONS
SAMBROOK, J.FRITSCH, E. F.: "Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR PRESS
FROMMER, M. ET AL., PROC NATL ACAD SCI USA, vol. 89, 1992, pages 1827 - 31
GRIGG, G.CLARK, S., BIOESSAYS, vol. 16, 1994, pages 431 - 6
ALTSCHUL S.F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
STEPHEN F. ET AL., NUCLEIC ACIDS RES., vol. 25, 1997, pages 3389 - 3402
HIGGINS D.G. ET AL., METHODS IN ENZYMOLOGY, vol. 266, 1996, pages 383 - 402
LARKIN M.A. ET AL., BIOINFORMATICS (OXFORD, ENGLAND, vol. 23, no. 21, 2007, pages 2947 - 8
"PCR Primer: A Laboratory Manual", 1995, COLD SPRING HARBOR LABORATORIES
LI LCDAHIYA R: "MethPrimer: designing primers for methylation PCRs", BIOINFORMATICS, vol. 18, no. 11, November 2002 (2002-11-01), pages 1427 - 31
M. KANEHISA, NUCLEIC ACIDS RES., vol. 12, 1984, pages 203
HERMAN ET AL.: "Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands", PROC NATL ACAD SCI USA., vol. 93, no. 18, 3 September 1996 (1996-09-03), pages 9821 - 6, XP002542477, DOI: 10.1073/pnas.93.18.9821
ANDERSONYOUNG: "Quantitative Filter Hybridization", NUCLEIC ACID HYBRIDIZATION, 1985
ALLAWISANTALUCIA, JR., BIOCHEMISTRY, vol. 36, 1997, pages 10581 - 94
EADS ET AL., CANCER RES., vol. 59, 1999, pages 2302 - 2306
YU ET AL., BIOTECHNIQUES, vol. 23, 1997, pages 714 - 720
COTTRELL ET AL., NUCL. ACIDS RES., vol. 32, 2003, pages e10
RAND ET AL., NUCL. ACIDS RES., vol. 33, 2005, pages e 127
HOLLAND ET AL., PROC. NATL. ACAD. SCI. USA, vol. 88, 1991, pages 7276 - 7280
MHLANGAMALMBERG, METHODS, vol. 25, 2001, pages 463 - 471
FROMMER ET AL., PROC. NATL. ACAD. SCI. USA, vol. 89, 1992, pages 1827 - 1831
CLARK ET AL., NUCL. ACIDS RES., vol. 22, 1994, pages 2990 - 2997
UHLMANN ET AL., ELECTROPHORESIS, vol. 23, 2002, pages 4072 - 4079
LANDEGREN ET AL., GENOME RES., vol. 8, no. 8, 1998, pages 769 - 776
SOUTHERN ET AL., GENOMICS, vol. 13, 1992, pages 1008 - 1017
MARGUILES ET AL., NATURE, vol. 437, no. 7057, 2005, pages 376 - 80
XIONGLAIRD, NUCL. ACIDS RES., vol. 25, 2001, pages 2532 - 2534
BIANCO ET AL., HUM. MUTAT., vol. 14, 1999, pages 289 - 293
ABRAMSSTANTON, METHODS ENZYMOL., vol. 212, 1992, pages 71 - 74
DENG ET AL., CHIN. J. CANCER RES., vol. 12, 2000, pages 171 - 191
KAWAI ET AL., MOL. CELL. BIOL., vol. 14, 1994, pages 7421 - 7427
GONZALGO ET AL., CANCER RES., vol. 57, pages 594 - 599
ADORJAN ET AL., NUCL. ACIDS RES., vol. 30, 2002, pages e21
FREDERICK M.AUSUBEL ET AL.: "Short Protocols in Molecular Biology", 1998, SCIENCE PRESS
T.R. CHURCH ET AL., GUT., vol. 63, 2014, pages 317 - 325
See also references of EP 3911756A4
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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