Title:
METHODS FOR MODULATING A SRC-1 CONDENSATE
Document Type and Number:
WIPO Patent Application WO/2022/171136
Kind Code:
A1
Abstract:
Provided are methods for modulating a SRC-1 condensate to regulate transcription of one or more genes, methods of treating diseases and conditions using SRC-1 inhibitors, and methods for screening of agents that modulate SRC-1 condensate.
Inventors:
ZHU GUANGYA (CN)
XIE JINGJING (CN)
ZHU JIDONG (CN)
GUO XIN (CN)
HE HAO (CN)
XIE JINGJING (CN)
ZHU JIDONG (CN)
GUO XIN (CN)
HE HAO (CN)
Application Number:
PCT/CN2022/075698
Publication Date:
August 18, 2022
Filing Date:
February 09, 2022
Export Citation:
Assignee:
ETERN BIOPHARMA SHANGHAI CO LTD (CN)
International Classes:
C12N15/12; A61K48/00; C12N15/63; C12N15/85; A61P35/00
Domestic Patent References:
| WO1997010337A1 | 1997-03-20 | |||
| WO1998057982A2 | 1998-12-23 |
Foreign References:
| CN110283825A | 2019-09-27 | |||
| CN109311856A | 2019-02-05 |
Other References:
ZHU GUANGYA; XIE JINGJING; FU ZHENZHEN; WANG MINGLIANG; ZHANG QICHEN; HE HAO; CHEN ZIJUN; GUO XIN; ZHU JIDONG: "Pharmacological inhibition of SRC-1 phase separation suppresses YAP oncogenic transcription activity", CELL RESEARCH, SPRINGER SINGAPORE, SINGAPORE, vol. 31, no. 9, 13 April 2021 (2021-04-13), Singapore , pages 1028 - 1031, XP037553421, ISSN: 1001-0602, DOI: 10.1038/s41422-021-00504-x
HNISZ DENES, SHRINIVAS KRISHNA, YOUNG RICHARD A., CHAKRABORTY ARUP K., SHARP PHILLIP A.: "A Phase Separation Model for Transcriptional Control", CELL, ELSEVIER, AMSTERDAM NL, vol. 169, no. 1, 23 March 2017 (2017-03-23), Amsterdam NL , pages 13 - 23, XP055806239, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.02.007
LAMAR JOHN M., XIAO YUXUAN, NORTON EMILY, JIANG ZHI-GANG, GERHARD GENEVIEVE M., KOONER SIMRIN, WARREN JANINE S.A., HYNES RICHARD O: "SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 294, no. 7, 7 June 2018 (2018-06-07), US , pages 2302 - 2317, XP055959003, ISSN: 0021-9258, DOI: 10.1074/jbc.RA118.004364
LIN YUAN, CURRIE SIMON L., ROSEN MICHAEL K.: "Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 292, no. 46, 1 November 2017 (2017-11-01), US , pages 19110 - 19120, XP055959005, ISSN: 0021-9258, DOI: 10.1074/jbc.M117.800466
HNISZ DENES, SHRINIVAS KRISHNA, YOUNG RICHARD A., CHAKRABORTY ARUP K., SHARP PHILLIP A.: "A Phase Separation Model for Transcriptional Control", CELL, ELSEVIER, AMSTERDAM NL, vol. 169, no. 1, 23 March 2017 (2017-03-23), Amsterdam NL , pages 13 - 23, XP055806239, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.02.007
LAMAR JOHN M., XIAO YUXUAN, NORTON EMILY, JIANG ZHI-GANG, GERHARD GENEVIEVE M., KOONER SIMRIN, WARREN JANINE S.A., HYNES RICHARD O: "SRC tyrosine kinase activates the YAP/TAZ axis and thereby drives tumor growth and metastasis", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 294, no. 7, 7 June 2018 (2018-06-07), US , pages 2302 - 2317, XP055959003, ISSN: 0021-9258, DOI: 10.1074/jbc.RA118.004364
LIN YUAN, CURRIE SIMON L., ROSEN MICHAEL K.: "Intrinsically disordered sequences enable modulation of protein phase separation through distributed tyrosine motifs", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 292, no. 46, 1 November 2017 (2017-11-01), US , pages 19110 - 19120, XP055959005, ISSN: 0021-9258, DOI: 10.1074/jbc.M117.800466
Attorney, Agent or Firm:
JUN HE LAW OFFICES (CN)
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