Title:
SPIRO-CONTAINING QUINAZOLINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2022/171135
Kind Code:
A1
Abstract:
Disclosed in the present invention is a spiro-containing quinazoline derivative. Specifically, the present invention relates to a compound shown in general formula (1) and a preparation method therefor, and a use of the compound of general formula (1), and each isomer thereof, each crystal form thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof as a G12C mutant K-Ras protein irreversible inhibitor in the preparation of a medication treating Ras-related diseases, such as tumors.
Inventors:
XIE YULI (CN)
CAO GANG (CN)
QIAN LIHUI (CN)
FAN HOUXING (CN)
CAO GANG (CN)
QIAN LIHUI (CN)
FAN HOUXING (CN)
Application Number:
PCT/CN2022/075694
Publication Date:
August 18, 2022
Filing Date:
February 09, 2022
Export Citation:
Assignee:
WIGEN BIOMEDICINE TECH SHANGHAI CO LTD (CN)
International Classes:
C07D471/10; A61K31/517; A61P35/00
Domestic Patent References:
| WO2020177629A1 | 2020-09-10 | |||
| WO2020216190A1 | 2020-10-29 | |||
| WO2020113071A1 | 2020-06-04 |
Foreign References:
| CN110267957A | 2019-09-20 |
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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