METHODS FOR PREPARING 2-ALKYNYLADENOSINE DERIVATIVES

Title:

METHODS FOR PREPARING 2-ALKYNYLADENOSINE DERIVATIVES

Document Type and Number:

WIPO Patent Application WO2004104017

Kind Code:

A3

Abstract:

Disclosed are methods for preparing 2-alkynyladenosine derivatives of Formula (A): or a stereoisomer, pharmaceutically acceptable salt, hydrate, solvate, acid salt hydrate or isomorphic crystalline form thereof, the method comprising the step ofcontacting 2-iodoadenosine-5'-N-ethyluronamide with a compound of Formula (B): wherein Z is -C(=O)OR or -CH20C(=O)R, where R is a C1 to C5 alkyl, preferably methyl. The methods are useful for preparing 2-alkynyladenosine derivatives that are, in certain embodiments, adenosine receptor agonists.

Inventors:

PICKERSGILL IAIN FRASER (US)
CHEESMAN EDWARD HOLLISTER (US)

Application Number:

PCT/US2004/015783

Publication Date:

March 24, 2005

Filing Date:

May 19, 2004

Export Citation:

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Assignee:

BRISTOL MEYERS SQUIBB PHARMA C (US)
PICKERSGILL IAIN FRASER (US)
CHEESMAN EDWARD HOLLISTER (US)

International Classes:

C07H19/00; C07H19/16; (IPC1-7): C07H19/16

Domestic Patent References:

WO2003029264A2

2003-04-10

Other References:

J.B. EPP, T.S. WIDLANSKI: "Facile preparation of nucleoside-5'-carboxylic acids", J. ORG. CHEM., vol. 64, 1999, pages 293 - 295, XP002300132
R. MALACHOWSKI ET AL.: "Untersuchungen in der Cyclohexangruppe", CHEM. BER., vol. 71, 1938, pages 759 - 767, XP002300305

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