Title:
METHODS OF PREVENTING OR TREATING BRAIN ISCHEMIA OR BRAIN INJURY
Document Type and Number:
WIPO Patent Application WO2003072543
Kind Code:
A3
Abstract:
The present invention relates to use of Narp inhibitor in order to promote or enhance recovery from ischemic events, particularly focal ischemia of the central nervous system, as well as for preventing or diminishing chronic degenerative changes.
Inventors:
FAERMAN ALEXANDER (IL)
KACHALSKY SYLVIA G (IL)
IDELSON GREGORY HIRSH (IL)
KACHALSKY SYLVIA G (IL)
IDELSON GREGORY HIRSH (IL)
Application Number:
PCT/US2003/005090
Publication Date:
May 21, 2004
Filing Date:
February 20, 2003
Export Citation:
Assignee:
QUARK BIOTECH INC (US)
FUJISAWA PHARMACEUTICAL CO (US)
FAERMAN ALEXANDER (IL)
KACHALSKY SYLVIA G (IL)
IDELSON GREGORY HIRSH (IL)
FUJISAWA PHARMACEUTICAL CO (US)
FAERMAN ALEXANDER (IL)
KACHALSKY SYLVIA G (IL)
IDELSON GREGORY HIRSH (IL)
International Classes:
A61K38/17; A61P25/00; A61K38/00; A61P25/28; A61P43/00; G01N33/50; G01N33/68; (IPC1-7): A61K38/17; G01N33/53
Foreign References:
| US4341762A | 1982-07-27 |
Other References:
ALAPE-GIRON A. ET AL.: "Elapid venom toxins: multiple recruitments of ancient scaffolds", EUR. J. BIOCHEM., vol. 259, 1999, pages 225 - 234, XP002976138
LIPPS B.V.: "Isolation of subunits alpha, beta and gamma of the complex taipoxin from the venom of Australian taipan snake (Oxyuranus s. scutellatus): characterization of beta taipoxin as a potent mitogen", TOXICON, vol. 38, 2000, pages 1845 - 1854, XP002976139
TZENG M-C. ET AL.: "Taipoxin-binding protein on synaptic membranes: identification by affinity labeling", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 165, no. 2, 15 December 1989 (1989-12-15), pages 689 - 694, XP002976140
KIRKPATRICK ET AL.: "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium binding protein 49 via NP1 and NP2.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 23, 9 June 2000 (2000-06-09), pages 17786 - 17792, XP002976141
LIPPS B.V.: "Isolation of subunits alpha, beta and gamma of the complex taipoxin from the venom of Australian taipan snake (Oxyuranus s. scutellatus): characterization of beta taipoxin as a potent mitogen", TOXICON, vol. 38, 2000, pages 1845 - 1854, XP002976139
TZENG M-C. ET AL.: "Taipoxin-binding protein on synaptic membranes: identification by affinity labeling", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 165, no. 2, 15 December 1989 (1989-12-15), pages 689 - 694, XP002976140
KIRKPATRICK ET AL.: "Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium binding protein 49 via NP1 and NP2.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 275, no. 23, 9 June 2000 (2000-06-09), pages 17786 - 17792, XP002976141
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