Title:
METHODS OF STRUCTURE-BASED DRUG DESIGN USING MS/NMR
Document Type and Number:
WIPO Patent Application WO2001062688
Kind Code:
A3
Abstract:
The present invention provides methods of structure-based drug design using mass spectrometry/NMR.
Inventors:
POWERS ROBERT
MOY FRANKLIN JOSEPH
SIEGEL MARSHALL MAYER
MOBILIO DOMINICK
MOY FRANKLIN JOSEPH
SIEGEL MARSHALL MAYER
MOBILIO DOMINICK
Application Number:
PCT/US2001/005495
Publication Date:
March 14, 2002
Filing Date:
February 21, 2001
Export Citation:
Assignee:
AMERICAN HOME PROD (US)
International Classes:
G01N27/62; B01J20/281; C07B61/00; G01N30/02; G01N30/04; G01N30/88; G01N33/15; G01N33/50; G01N33/53; G01N33/538; G01N33/542; G01N33/68; G01R33/465; G06Q50/00; (IPC1-7): G01N33/53; G01N33/538; G01N33/542; G01N33/68
Domestic Patent References:
| WO1997018469A2 | 1997-05-22 | |||
| WO1997037953A1 | 1997-10-16 | |||
| WO2000047999A1 | 2000-08-17 |
Foreign References:
| US5891742A | 1999-04-06 | |||
| EP0981049A1 | 2000-02-23 |
Other References:
S B SHUKER ET AL: "Discovering High-Affinity Ligands for Proteins: SAR by NMR", SCIENCE,AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,,US, no. 274, 1996, pages 1531 - 1534, XP002074440, ISSN: 0036-8075
MOY F J ET AL: "MS/NMR: a structure-based approach for discovering protein ligands and for drug design by coupling size exclusion chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy.", ANALYTICAL CHEMISTRY, (2001 FEB 1) 73 (3) 571-81., XP002173753
DEAR G J ET AL: "Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy", JOURNAL OF CHROMATOGRAPHY. BIOMEDICAL APPLICATIONS,ELSEVIER, AMSTERDAM,NL, vol. 748, no. 1, 1 October 2000 (2000-10-01), pages 281 - 293, XP004224403, ISSN: 0378-4347
MOY F J ET AL: "MS/NMR: a structure-based approach for discovering protein ligands and for drug design by coupling size exclusion chromatography, mass spectrometry, and nuclear magnetic resonance spectroscopy.", ANALYTICAL CHEMISTRY, (2001 FEB 1) 73 (3) 571-81., XP002173753
DEAR G J ET AL: "Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography-mass spectrometry-nuclear magnetic resonance spectroscopy", JOURNAL OF CHROMATOGRAPHY. BIOMEDICAL APPLICATIONS,ELSEVIER, AMSTERDAM,NL, vol. 748, no. 1, 1 October 2000 (2000-10-01), pages 281 - 293, XP004224403, ISSN: 0378-4347
Download PDF: