METHODS OF TREATING SYSTEMIC LUPUS ERYTHEMATOSUS USING BTK INHIBITORS

Title:

METHODS OF TREATING SYSTEMIC LUPUS ERYTHEMATOSUS USING BTK INHIBITORS

Document Type and Number:

WIPO Patent Application WO/2022/105870

Kind Code:

A1

Abstract:

Provided herein are methods of treating systemic lupus erythematosus including lupus nephritis, in particularly active proliferative lupus nephritis in a subject with (S) -7- (1-acryloylpiperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahydropyrazolo- [1, 5-a] pyrimidine-3-carboxamide or a pharmaceutically acceptable salt thereof.

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Inventors:

HU NAN (CN)
LI SHURAN (CN)
SONG XIAOMIN (CN)
YAO ZHEN (CN)
GUO YUNHANG (CN)
WANG ZHIWEI (CN)

Application Number:

PCT/CN2021/131725

Publication Date:

May 27, 2022

Filing Date:

November 19, 2021

Export Citation:

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Assignee:

BEIGENE LTD (GB)
HU NAN (CN)

International Classes:

A61K31/519; A61P37/00

Domestic Patent References:

WO2017218844A2	2017-12-21
WO2020055698A1	2020-03-19
WO2020024916A1	2020-02-06
WO2019208805A1	2019-10-31

Foreign References:

CN109563099A	2019-04-02
CN107344940A	2017-11-14

Other References:

WATTERSON，S.H. ET AL.: "Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton’s Tyrosine Kinase (BTK).", JOURNAL OF MEDICINAL CHEMISTRY., vol. 62, 20 March 2019 (2019-03-20), pages 3228 - 3250, XP055781288, DOI: 10.1021/acs.jmedchem.9b00167

Attorney, Agent or Firm:

WU, FENG & ZHANG (CN)

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