Title:
METHODS OF TREATMENT USING WISP POLYPEPTIDES
Document Type and Number:
WIPO Patent Application WO2002033085
Kind Code:
A9
Abstract:
The present invention relates to methods for the treatment and repair of cartilage, including cartilage damaged by injury or degenerative cartilagenous disorders, including arthritis, comprising the administration of WISP polypeptide. Optionally, the administration may be in combination with one or more cartilage agents (e.g., peptide growth factor, catabolism antagonist, osteo-, synovial, anti-inflammatory factor). Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of WISP polypeptide in combination with standard surgical techniques. Alternatively, the method provides for the treatment and repair of cartilage damaged by injury or degenerative cartilagenous disorders comprising the administration of chondrocytes previously treated with an effective amount of WISP polypeptide.
Inventors:
DESNOYER LUC (US)
FILVAROFF ELLEN H (US)
PENNICA DIANE (US)
FILVAROFF ELLEN H (US)
PENNICA DIANE (US)
Application Number:
PCT/US2001/032142
Publication Date:
July 25, 2002
Filing Date:
October 12, 2001
Export Citation:
Assignee:
GENENTECH INC (US)
DESNOYER LUC (US)
FILVAROFF ELLEN H (US)
PENNICA DIANE (US)
DESNOYER LUC (US)
FILVAROFF ELLEN H (US)
PENNICA DIANE (US)
International Classes:
A61P19/02; A61P29/00; C07K14/47; C07K14/475; A61K38/00; C12N15/12; (IPC1-7): C12N15/12; C07K14/47; A61K38/17; C12N15/62
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