Title:
METHODS OF USE OF BETA 1-INTEGRIN INHIBITORS
Document Type and Number:
WIPO Patent Application WO2000056350
Kind Code:
A9
Abstract:
The present invention provides methods that use agents capable of one or more of the following: inhibiting leukocyte mediated destruction of tissues, especially after injuries to tissue due to heat or cold (i.e., burns or frostbite), light, electricity, chemicals, or other agents that cause tissue injury and destruction; inhibiting leukocyte mediated destruction of tissues after myocardial infarction, CNS ischemic injury (e.g., stroke), angioplasty, surgical incisions, injury-mediated trauma, and transplant reperfusion; inhibiting angiogenesis; inhibiting cancer cell metastasis, motility, and/or migration within tissue; restoring and/or potentiating the induction of programmed cell death in cancerous tissues or restoring normal cellular phenotype to cancerous tissue; inhibiting osteoclast adhesion and bone resorption; and/or inhibiting stem cell adhesion to bone marrow.
More Like This:
Inventors:
MCCARTHY JAMES B (US)
MILESKI WILLIAM J (US)
JAMIESON GORDON A JR (US)
LOW WALTER C (US)
SAWCHUK RONALD J (US)
FURCHT LEO T (US)
MILESKI WILLIAM J (US)
JAMIESON GORDON A JR (US)
LOW WALTER C (US)
SAWCHUK RONALD J (US)
FURCHT LEO T (US)
Application Number:
PCT/US2000/007680
Publication Date:
June 27, 2002
Filing Date:
March 22, 2000
Export Citation:
Assignee:
UNIV MINNESOTA (US)
UNIV TEXAS (US)
SENTRON MEDICAL INC (US)
MCCARTHY JAMES B (US)
MILESKI WILLIAM J (US)
JAMIESON GORDON A JR (US)
LOW WALTER C (US)
SAWCHUK RONALD J (US)
FURCHT LEO T (US)
UNIV TEXAS (US)
SENTRON MEDICAL INC (US)
MCCARTHY JAMES B (US)
MILESKI WILLIAM J (US)
JAMIESON GORDON A JR (US)
LOW WALTER C (US)
SAWCHUK RONALD J (US)
FURCHT LEO T (US)
International Classes:
A61K38/39; A61P9/00; A61P17/00; A61P19/00; A61P25/00; A61P29/00; A61P35/00; A61P41/00; (IPC1-7): A61K38/06; A61K38/07; A61K38/08; A61K38/39; A61P9/00; A61P17/00; A61P19/00; A61P25/00; A61P29/00; A61P35/00; A61P41/00
Download PDF: