Title:
MICROMOLECULAR OXATHIAZINE DERIVATIVE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/238587
Kind Code:
A1
Abstract:
A micromolecular oxathiazine derivative, which belongs to the field of organic synthesis medicines and has the general formula as shown below: the micromolecular oxathiazine derivative can be used as a positive allosteric modulator of an AMPA receptor, which proves that the compound can positively regulate the AMPA receptor, so that the conformation after an agonist (such as endogenous neurotransmitter glutamic acid) is combined with the receptor is more stable, thereby reducing the deactivation rate of the receptor, inhibiting the desensitization of the receptor, and enhancing the function of the AMPA receptor.
Inventors:
LI TAO (CN)
QI XUEYU (CN)
YU XUELI (CN)
QI XUEYU (CN)
YU XUELI (CN)
Application Number:
PCT/CN2021/091631
Publication Date:
December 02, 2021
Filing Date:
April 30, 2021
Export Citation:
Assignee:
WEST CHINA HOSPITAL OF SICHUAN UNIV (CN)
International Classes:
C07D291/08; A61K31/5415; A61P25/16; A61P25/18; A61P25/24; A61P25/28; C07D419/04; C07D419/10
Domestic Patent References:
| WO2008073956A2 | 2008-06-19 | |||
| WO2006113432A2 | 2006-10-26 | |||
| WO2013151930A1 | 2013-10-10 |
Foreign References:
| CN111559990A | 2020-08-21 | |||
| CN100390157C | 2008-05-28 | |||
| CN103153973A | 2013-06-12 |
Other References:
SHI LEI, BAO ROBERT LI-YUAN, ZHENG LIMIN, ZHAO RONG: "B(C 6 F 5 ) 3 -Catalyzed Reduction of Cyclic N -Sulfonyl Ketimines", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2019, no. 38, 17 October 2019 (2019-10-17), DE , pages 6550 - 6556, XP055872050, ISSN: 1434-193X, DOI: 10.1002/ejoc.201900706
DATABASE REGISTRY 27 November 2018 (2018-11-27), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -2249991-11-3 REGISTRY ED -Entered STN: 27 Nov 2018 CN -1,2,3-Benzoxathiazine, 6-chloro-3,4-dihydro-, 2,2-dioxide (CA INDEX NAME)", XP055872058, retrieved from STN Database accession no. 2249991-11-3
DATABASE REGISTRY 27 November 2018 (2018-11-27), ANONYMOUS: "/1 -(C) FILE REGISTRY RN -2249991-11-3 REGISTRY ED -Entered STN: 27 Nov 2018 CN -1,2,3-Benzoxathiazine, 6-chloro-3,4-dihydro-, 2,2-dioxide (CA INDEX NAME)", XP055872058, retrieved from STN Database accession no. 2249991-11-3
Attorney, Agent or Firm:
CHENGDU JUNHEJI PATENT OFFICE (ORDINARY PARTNERSHIP) (CN)
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