Title:
MICRORNA FOR IDENTIFICATION OF EXPOSURE TO PARTICULATE MATTER 2.5, AND IDENTIFICATION METHOD USING SAME
Document Type and Number:
WIPO Patent Application WO/2015/005532
Kind Code:
A1
Abstract:
The present invention relates to a microRNA for the identification of exposure to particulate matter 2.5 (PM2.5), and an identification method using same. More specifically, the present invention was found to be capable of being effectively used as a tool for monitoring PM2.5, for determining the hazard of PM2.5, and for investigating the mechanism of toxicity caused by PM2.5, by screening one type of overexpressed microRNA of at least 1.300-fold expression and one type of underexpressed microRNA of at most 0.769-fold expression as a result of having pneumocytes or lung cancer cells exposed to a water-soluble extract of PM2.5 and an organic extract of PM2.5, and by using the two types of microRNAs as biomarkers.
Inventors:
RYU JAE CHUN (KR)
SHIN CHAN YOUNG (KR)
SONG MI-KYUNG (KR)
LEE HYO SUN (KR)
CHOI HAN-SEAM (KR)
SHIN CHAN YOUNG (KR)
SONG MI-KYUNG (KR)
LEE HYO SUN (KR)
CHOI HAN-SEAM (KR)
Application Number:
PCT/KR2013/008899
Publication Date:
January 15, 2015
Filing Date:
October 04, 2013
Export Citation:
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
C12Q1/68; C12N15/11; G01N33/574
Foreign References:
| KR20130029567A | 2013-03-25 | |||
| KR20130029566A | 2013-03-25 |
Other References:
SHIN ET AL.: "Particulate matter 2.5 exposure modulates microRNA expression patterns in A549 human alveolar epithelial cells", 5TH INTERNATIONAL CONFERENCE ON ENVIRONMENTAL HEALTH SCIENCE, 18 October 2012 (2012-10-18)
SHIN ET AL.: "Altered microRNA profiling by particulate matter 2.5 exposure in A549 human alveolar epithelial cells", 8TH INTERNATIONAL CONFERENCE ON TOXICOGENOMICS, 1 November 2012 (2012-11-01)
BOLLATI ET AL.: "Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytes", ENVIRONMENTAL HEALTH PERSPECTIVES, vol. 118, no. 6, June 2010 (2010-06-01)
WILKER ET AL.: "Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the normative aging study", ENVIRONMENTAL HEALTH, vol. 10, 21 May 2011 (2011-05-21), pages 1 - 9
SHIN ET AL.: "Altered microRNA profiling by particulate matter 2.5 exposure in A549 human alveolar epithelial cells", 8TH INTERNATIONAL CONFERENCE ON TOXICOGENOMICS, 1 November 2012 (2012-11-01)
BOLLATI ET AL.: "Exposure to metal-rich particulate matter modifies the expression of candidate microRNAs in peripheral blood leukocytes", ENVIRONMENTAL HEALTH PERSPECTIVES, vol. 118, no. 6, June 2010 (2010-06-01)
WILKER ET AL.: "Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the normative aging study", ENVIRONMENTAL HEALTH, vol. 10, 21 May 2011 (2011-05-21), pages 1 - 9
Attorney, Agent or Firm:
LEE, WON-HEE (KR)
이원희 (KR)
이원희 (KR)
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