Title:
MINI-BRAIN STRUCTURE AND CONSTRUCTION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2022/080974
Kind Code:
A1
Abstract:
The present invention relates to a mini-brain structure and a construction method therefor and, more specifically, to a mini-brain and a construction method therefor, wherein induced pluripotent stem cells can be used to prepare brain organoids for different brain regions accounting for the cerebrum, the mesencephalon, the cerebellum, the thalamus, and the like and the organoids are combined into single structures, thereby making it possible to further effectively implement actual brain functions and wherein brain organoids for different brain regions can be selectively combined into single structures according to purposes, thereby achieving the aim of using brain organoids and enhancing convenience and economical benefit.
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Inventors:
CHOI JEONG WOO (KR)
PARK SOO JEONG (KR)
LEE SANG NAM (KR)
PARK SOO JEONG (KR)
LEE SANG NAM (KR)
Application Number:
PCT/KR2021/014414
Publication Date:
April 21, 2022
Filing Date:
October 15, 2021
Export Citation:
Assignee:
SOGANG UNIV RESEARCH ＆ BUSINESS DEVELOPMENT FOUNDATION (KR)
UNIANCE GENE (KR)
UNIANCE GENE (KR)
International Classes:
C12N11/14; C12Q1/28; C12Q1/54; B82Y15/00
Domestic Patent References:
| WO2017117547A1 | 2017-07-06 |
Foreign References:
| KR20200081294A | 2020-07-07 | |||
| KR20180075074A | 2018-07-04 |
Other References:
QIAN XUYU, SONG HONGJUN, MING GUO-LI: "Brain organoids: advances, applications and challenges", DEVELOPMENT, THE COMPANY OF BIOLOGISTS LTD., GB, vol. 146, no. 8, 15 April 2019 (2019-04-15), GB , pages dev166074 - 12, XP055921318, ISSN: 0950-1991, DOI: 10.1242/dev.166074
ARLOTTA PAOLA: "Generating 3D Cerebral Organoids From Human Pluripotent Stem Cells to Model Cortical Development and Disease", NOTES OF THE DEPARTMENT OF STEM CELL AND REGENERATIVE BIOLOGY, HARVARD UNIVERSITY CAMBRIDGE, MASSACHUSETTS, 1 January 2015 (2015-01-01), Massachusetts, pages 41 - 50, XP055921320, Retrieved from the Internet [retrieved on 20220516]
ARLOTTA PAOLA: "Generating 3D Cerebral Organoids From Human Pluripotent Stem Cells to Model Cortical Development and Disease", NOTES OF THE DEPARTMENT OF STEM CELL AND REGENERATIVE BIOLOGY, HARVARD UNIVERSITY CAMBRIDGE, MASSACHUSETTS, 1 January 2015 (2015-01-01), Massachusetts, pages 41 - 50, XP055921320, Retrieved from the Internet
Attorney, Agent or Firm:
KIM, Hyun Jin (KR)
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