Title:
MIXTURE OF PEPTIDES FROM C AND NS3 PROTEINS OF THE HEPATITIS C VIRUS AND APPLICATIONS THEREOF
Document Type and Number:
WIPO Patent Application WO2004014936
Kind Code:
A3
Abstract:
The invention relates to a peptide mixture including at least two different peptides from the hepatitis C virus (HCV), whereby at least one of them is a peptide from the C protein binding to at least four different HLA-II molecules, the occurrence of which exceeds 5 % in the Caucasian population with a binding activity < 1,000 nM. Said invention also relates to the applications thereof as a drug useful in the prevention and treatment of HCV infections or as a diagnostic reagent for HCV-specific T lymphocytes.
Inventors:
MAILLERE BERNARD (FR)
GEORGES BERTRAND (FR)
CASTELLI FLORENCE (FR)
BOUZIDI AHMED (FR)
GEORGES BERTRAND (FR)
CASTELLI FLORENCE (FR)
BOUZIDI AHMED (FR)
Application Number:
PCT/FR2003/002446
Publication Date:
July 22, 2004
Filing Date:
August 01, 2003
Export Citation:
Assignee:
COMMISSARIAT ENERGIE ATOMIQUE (FR)
SEDAC THERAPEUTICS (FR)
MAILLERE BERNARD (FR)
GEORGES BERTRAND (FR)
CASTELLI FLORENCE (FR)
BOUZIDI AHMED (FR)
SEDAC THERAPEUTICS (FR)
MAILLERE BERNARD (FR)
GEORGES BERTRAND (FR)
CASTELLI FLORENCE (FR)
BOUZIDI AHMED (FR)
International Classes:
A61P31/14; C07K14/18; C12N15/51; G01N33/569; A61K39/00; (IPC1-7): C07K14/18; C12N15/51; C12N15/63; C12Q1/02; G01N33/68; G01N33/80; A61K48/00; A61K39/295; A61P31/14
Domestic Patent References:
| WO2002034770A1 | 2002-05-02 | |||
| WO1995027733A1 | 1995-10-19 |
Other References:
LAMONACA V ET AL: "CONSERVED HEPATITIS C VIRUS SEQUENCES ARE HIGHLY IMMUNOGENIC FOR CD4+ T CELLS: IMPLICATIONS FOR VACCINE DEVELOPMENT", HEPATOLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, VOL. 30, NR. 4, PAGE(S) 1088-1098, ISSN: 0270-9139, XP001027157
DIEPOLDER H M ET AL: "Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection", THE LANCET, VOL. 346, PAGE(S) 1006-1007, 14 OCTOBRE 1995, ISSN: 0270-9139, XP001147781
HITOMI Y ET AL: "HIGH EFFICIENCY PROKARYOTIC EXPRESSION AND PURIFICATION OF A PROTION OF THE HEPATITIS C CORE PROTEIN AND ANALYSIS OF THE IMMUNE RESPONSE TO RECOMBINANT PROTEIN IN BALB/C MICE", VRAL IMMUNOLOGY, VOL. 8, NR. 2, PAGE8S9 109-119, 1995, ISSN: 0270-9139, XP000978724
DIEPOLDER H M ET AL: "Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection", THE LANCET, VOL. 346, PAGE(S) 1006-1007, 14 OCTOBRE 1995, ISSN: 0270-9139, XP001147781
HITOMI Y ET AL: "HIGH EFFICIENCY PROKARYOTIC EXPRESSION AND PURIFICATION OF A PROTION OF THE HEPATITIS C CORE PROTEIN AND ANALYSIS OF THE IMMUNE RESPONSE TO RECOMBINANT PROTEIN IN BALB/C MICE", VRAL IMMUNOLOGY, VOL. 8, NR. 2, PAGE8S9 109-119, 1995, ISSN: 0270-9139, XP000978724
Download PDF:
Previous Patent: PROCESS AND NEW INTERMEDIATES FOR THE PREPARATION OF STEROIDS WITH A PROGESTOGEN ACTIVITY
Next Patent: THROMBIN PEPTIDE DERIVATIVES
Next Patent: THROMBIN PEPTIDE DERIVATIVES