Title:
PROCESS AND NEW INTERMEDIATES FOR THE PREPARATION OF STEROIDS WITH A PROGESTOGEN ACTIVITY
Document Type and Number:
WIPO Patent Application WO2004014934
Kind Code:
A3
Abstract:
The present invention relates to a new process of synthesis and to some new intermediates for the preparation of steroids with progestogen activity, more particularly, for the preparation of Desogestrel of formula (I). Said process is characterized by the regioselective reduction of the compound of formula (XIIa) to give the intermediate of formula (XIVa).
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Inventors:
GRISENTI PARIDE (IT)
PECORA FABIO (IT)
VERZA ELISA (IT)
LEONI MASSIMO (IT)
BOSSI LAURA (IT)
PECORA FABIO (IT)
VERZA ELISA (IT)
LEONI MASSIMO (IT)
BOSSI LAURA (IT)
Application Number:
PCT/EP2003/008505
Publication Date:
May 21, 2004
Filing Date:
July 31, 2003
Export Citation:
Assignee:
POLI IND CHIMICA SPA (IT)
GRISENTI PARIDE (IT)
PECORA FABIO (IT)
VERZA ELISA (IT)
LEONI MASSIMO (IT)
BOSSI LAURA (IT)
GRISENTI PARIDE (IT)
PECORA FABIO (IT)
VERZA ELISA (IT)
LEONI MASSIMO (IT)
BOSSI LAURA (IT)
International Classes:
C07J1/00; C07J11/00; C07J21/00; (IPC1-7): C07J11/00; C07J21/00
Foreign References:
| US5831104A | 1998-11-03 | |||
| GB1128044A | 1968-09-25 |
Other References:
S. SCHWARZ ET. AL.: "Synthesis of 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol (Desogestrel) and its Main Metabolite 3-Oxo-Desogestrel.", TETRAHEDRON, vol. 50, no. 36, 1994, pages 10709 - 20, XP000611446
H. GAO ET. AL.: "Synthesis of 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one (3-oxo desogestrel).", STEROIDS, vol. 62, 1997, pages 399 - 402, XP004082728
H. GAO ET. AL.: "Synthesis of 13-ethyl-17-hydroxy-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one (3-oxo desogestrel).", STEROIDS, vol. 62, 1997, pages 399 - 402, XP004082728
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