Title:
MODIFICATION METHOD FOR PRECURSOR OF β-KETOIMINE LIGAND, AND PRODUCT THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/116940
Kind Code:
A1
Abstract:
The present invention relates to a simple method for modifying a precursor of a β-ketoimine ligand, comprising: reacting an LPhH2 solution with a lithium compound; then adding halogenated hydrocarbon for a C-C bond coupling reaction; and adding an acid solution to finish the modification of the precursor of the β-ketoimine ligand to obtain terminal-alkylated ketoimine. The present invention relates to a simple method for modifying the precursor of the β-ketoimine ligand, and specifically relates to removing a proton in the precursor of the β-ketoimine ligand at the α position by means of commercialized n-butyllithium to form a deprotonated β-ketoimine lithium compound, and implementing alkylation at the α position of ketocarbonyl by means of C-C bond coupling, thereby achieving convenient modification for the precursor of the β-ketoimine ligand.
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Inventors:
XUE MINGQIANG (CN)
ZHOU SHUAI (CN)
ZHU XU (CN)
XU XIAOJUAN (CN)
KANG ZIHAN (CN)
ZHOU SHUAI (CN)
ZHU XU (CN)
XU XIAOJUAN (CN)
KANG ZIHAN (CN)
Application Number:
PCT/CN2022/143978
Publication Date:
June 29, 2023
Filing Date:
December 30, 2022
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C07C225/14; C07C221/00
Foreign References:
| CN111747972A | 2020-10-09 | |||
| CN107827764A | 2018-03-23 | |||
| CN101314574A | 2008-12-03 | |||
| CN101602681A | 2009-12-16 |
Other References:
ZHOU SHUAI, XU XIAOJUAN, ZHU XU, ZHENG YU, CHEN SUFANG, XUE MINGQIANG: "A facile approach to C -functionalized β-ketoimine compounds via terminal alkylation of a tetralithiated intermediate", ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 20, no. 21, 1 June 2022 (2022-06-01), pages 4289 - 4292, XP093075208, ISSN: 1477-0520, DOI: 10.1039/D2OB00640E
ZHU YUNBO, ZHANG LONG, LUO SANZHONG: "Asymmetric α-Photoalkylation of β-Ketocarbonyls by Primary Amine Catalysis: Facile Access to Acyclic All-Carbon Quaternary Stereocenters", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 42, 22 October 2014 (2014-10-22), pages 14642 - 14645, XP093075209, ISSN: 0002-7863, DOI: 10.1021/ja508605a
ZHU YUNBO, ZHANG LONG, LUO SANZHONG: "Asymmetric α-Photoalkylation of β-Ketocarbonyls by Primary Amine Catalysis: Facile Access to Acyclic All-Carbon Quaternary Stereocenters", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 42, 22 October 2014 (2014-10-22), pages 14642 - 14645, XP093075209, ISSN: 0002-7863, DOI: 10.1021/ja508605a
Attorney, Agent or Firm:
SUZHOU CREATOR PATENT AND TRADEMARK AGENCY, LTD (CN)
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