MODIFIED 2' AND 3' -NUCLEOSIDE PRODUGS FOR TREATING FLAVIRIDAE INFECTIONS

Title:

MODIFIED 2' AND 3' -NUCLEOSIDE PRODUGS FOR TREATING FLAVIRIDAE INFECTIONS

Document Type and Number:

WIPO Patent Application WO2004002999

Kind Code:

A8

Abstract:

2' and/or 3' prodrugs of l', 2', 3' or 4'-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

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Inventors:

SOMMADOSSI JEAN-PIERRE (US)
LA COLLA POALO (IT)
STORER RICHARD (GB)
GOSSELIN GILLES (FR)

Application Number:

PCT/IB2003/003246

Publication Date:

February 17, 2005

Filing Date:

June 27, 2003

Export Citation:

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Assignee:

IDENIX CAYMAN LTD (KY)
CENTRE NAT RECH SCIENT (FR)
UNIV CAGLIARI (IT)
SOMMADOSSI JEAN-PIERRE (US)
LA COLLA POALO (IT)
STORER RICHARD (GB)
GOSSELIN GILLES (FR)

International Classes:

C07H19/06; A61K9/20; A61K9/48; A61K31/7056; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K38/00; A61K38/21; A61K45/00; A61P31/14; A61P43/00; C07H19/00; C07H19/04; C07H19/044; C07H19/048; C07H19/052; C07H19/056; C07H19/067; C07H19/10; C07H19/12; C07H19/14; C07H19/16; C07H19/167; C07H19/20; C07H19/22; C07H19/23; (IPC1-7): C07H19/06; C07H19/10; C07H19/16; C07H19/20; C07H19/04; C07H19/044; C07H19/048; C07H19/052; C07H19/056; C07H19/12; C07H19/14; C07H19/22; C07H19/23; A61K31/7056; A61K31/706; A61K31/7064; A61P31/14

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