Title:
MODIFIED FILAMENTOUS FUNGUS, AND METHOD FOR PRODUCING PROTEIN USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/215618
Kind Code:
A1
Abstract:
Provided are a modified filamentous fungus that exhibits an enhanced protein productivity, and a method for producing protein using this modified filamentous fungus. The modified filamentous fungus expresses an ACE3 modification wherein this ACE3 modification is a modification in which substantially all of the Zn(II)2Cys6-type DNA binding domain of ACE3 has been deleted. The protein production method comprises culturing this modified filamentous fungus.
Inventors:
ARAI TOSHIHARU (JP)
KODAMA HIROSHI (JP)
KODAMA HIROSHI (JP)
Application Number:
PCT/JP2022/015855
Publication Date:
October 13, 2022
Filing Date:
March 30, 2022
Export Citation:
Assignee:
KAO CORP (JP)
International Classes:
C12N1/15; C12N9/42; C12N15/31; C12P21/00
Domestic Patent References:
| WO2018067599A1 | 2018-04-12 | |||
| WO2013115305A1 | 2013-08-08 |
Foreign References:
| JP2019528797A | 2019-10-17 | |||
| US20130078674A1 | 2013-03-28 | |||
| JP6169077B2 | 2017-07-26 | |||
| JP5366286B2 | 2013-12-11 | |||
| US9512415B2 | 2016-12-06 | |||
| JP2020042489W | 2020-11-13 |
Other References:
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MARI HÄKKINEN;MARI J VALKONEN;ANN WESTERHOLM-PARVINEN;NINA ARO;MIKKO ARVAS;MARIKA VITIKAINEN;MERJA PENTTILÄ;MARKKU SALOHEIMO;TIINA: "Screening of candidate regulators for cellulase and hemicellulase production in Trichoderma reesei and identification of a factor essential for cellulase production", BIOTECHNOLOGY FOR BIOFUELS, vol. 7, no. 1, 28 January 2014 (2014-01-28), pages 14, XP021176306, ISSN: 1754-6834, DOI: 10.1186/1754-6834-7-14
ZHANG JIAJIA, CHEN YUMENG, WU CHUAN, LIU PEI, WANG WEI, WEI DONGZHI: "The transcription factor ACE3 controls cellulase activities and lactose metabolism via two additional regulators in the fungus Trichoderma reesei", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 294, no. 48, 1 November 2019 (2019-11-01), US , pages 18435 - 18450, XP055825541, ISSN: 0021-9258, DOI: 10.1074/jbc.RA119.008497
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J BIOL CHEM., 2019
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BIOTECH. BIOFUELS, vol. 10, 2017, pages 30
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BIOTECHNOL. BIOENG, vol. 109, no. 1, 2012, pages 92 - 99
CHEN YUMENG, WU CHUAN, FAN XINGJIA, ZHAO XINQING, ZHAO XIHUA, SHEN TAO, WEI DONGZHI, WANG WEI: "Engineering of Trichoderma reesei for enhanced degradation of lignocellulosic biomass by truncation of the cellulase activator ACE3", BIOTECHNOLOGY FOR BIOFUELS, vol. 13, no. 1, 1 December 2020 (2020-12-01), XP055976462, DOI: 10.1186/s13068-020-01701-3
MARI HÄKKINEN;MARI J VALKONEN;ANN WESTERHOLM-PARVINEN;NINA ARO;MIKKO ARVAS;MARIKA VITIKAINEN;MERJA PENTTILÄ;MARKKU SALOHEIMO;TIINA: "Screening of candidate regulators for cellulase and hemicellulase production in Trichoderma reesei and identification of a factor essential for cellulase production", BIOTECHNOLOGY FOR BIOFUELS, vol. 7, no. 1, 28 January 2014 (2014-01-28), pages 14, XP021176306, ISSN: 1754-6834, DOI: 10.1186/1754-6834-7-14
ZHANG JIAJIA, CHEN YUMENG, WU CHUAN, LIU PEI, WANG WEI, WEI DONGZHI: "The transcription factor ACE3 controls cellulase activities and lactose metabolism via two additional regulators in the fungus Trichoderma reesei", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, vol. 294, no. 48, 1 November 2019 (2019-11-01), US , pages 18435 - 18450, XP055825541, ISSN: 0021-9258, DOI: 10.1074/jbc.RA119.008497
CURR. GENOMICS, vol. 14, 2013, pages 230 - 249
BMC GENOMICS, vol. 16, 2015, pages 326
J BIOL CHEM., 2019
BIOTECH. BIOFUELS, vol. 7, 2014, pages 14
BIOTECH. BIOFUELS, vol. 13, 2020, pages 137
BIOTECH. BIOFUELS, vol. 6, 2013, pages 62
BIOTECH. BIOFUELS, vol. 10, 2017, pages 30
SCIENCE, vol. 227, 1985, pages 1435 - 1441
THOMPSON, J. D. ET AL., NUCLEIC ACIDS RES., vol. 22, 1994, pages 4673 - 4680
"NCBI", Database accession no. XP _006966092.1
ENZYME, MICROBIAL TECHNOLOGY, vol. 82, 2016, pages 89 - 95
BIOSCI. BIOTECHNOL. BIOCHEM., vol. 60, 1996, pages 383 - 389
BIOSCI. BIOTECHNOL. BIOCHEM., vol. 62, 1998, pages 1615 - 1618
BIOTECHNOL. BIOENG, vol. 109, no. 1, 2012, pages 92 - 99
Attorney, Agent or Firm:
THE PATENT CORPORATE BODY ARUGA PATENT OFFICE (JP)
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